Polycyclic N-heterocyclic compounds. 50 [1]. Synthesis and pharmacological evaluation of 2,3,6,7-tetrahydrothieno[2,3-h]- imidazo[2,1 - f] [1,6] naphthyridines, 3,4,7,8-tetrahydro-2H-thieno[2,3-h]pyrimido[2,1- f][1,6]naphthyridines and their precursor

Kenji Sasaki, Abu Shara S Rouf, Takashi Hirota, Naoki Nakaya

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    Some novel 5-hydroxyalkylamino-1,2-dihydrothieno[2,3- h][1,6]naphthyridines were prepared by the reaction of 5-chloro-l,2- dihydrothieno[2,3-h][1,6]naphthyridine derivatives with some aminoalcohols in the presence of base. These derivatives were cyclized to the corresponding imidazo or pyrimido derivatives. The bronchodilatory activity of these compounds was evaluated on the basis of their relaxation activity to tracheal contraction induced by carbamylcholine chloride as a primary in vitro assays. Effect of some naphthyridines on carbamylcholine chloride-induced contractions of trachea in the presence or absence of milrinone or 4-(3- butoxy-4-methoxyphenyl)imidazolidin-2-one, which is inhibitor of phosphodiesterase III or IV, were also evaluated.

    Original languageEnglish
    Pages (from-to)461-465
    Number of pages5
    JournalJournal of Heterocyclic Chemistry
    Volume36
    Issue number2
    Publication statusPublished - 1999

    Fingerprint

    Naphthyridines
    Heterocyclic Compounds
    Carbachol
    Derivatives
    Chlorides
    Type 3 Cyclic Nucleotide Phosphodiesterases
    Type 4 Cyclic Nucleotide Phosphodiesterase
    Milrinone
    Assays

    ASJC Scopus subject areas

    • Organic Chemistry

    Cite this

    @article{3427747c66944f13adf0f7a3845c0553,
    title = "Polycyclic N-heterocyclic compounds. 50 [1]. Synthesis and pharmacological evaluation of 2,3,6,7-tetrahydrothieno[2,3-h]- imidazo[2,1 - f] [1,6] naphthyridines, 3,4,7,8-tetrahydro-2H-thieno[2,3-h]pyrimido[2,1- f][1,6]naphthyridines and their precursor",
    abstract = "Some novel 5-hydroxyalkylamino-1,2-dihydrothieno[2,3- h][1,6]naphthyridines were prepared by the reaction of 5-chloro-l,2- dihydrothieno[2,3-h][1,6]naphthyridine derivatives with some aminoalcohols in the presence of base. These derivatives were cyclized to the corresponding imidazo or pyrimido derivatives. The bronchodilatory activity of these compounds was evaluated on the basis of their relaxation activity to tracheal contraction induced by carbamylcholine chloride as a primary in vitro assays. Effect of some naphthyridines on carbamylcholine chloride-induced contractions of trachea in the presence or absence of milrinone or 4-(3- butoxy-4-methoxyphenyl)imidazolidin-2-one, which is inhibitor of phosphodiesterase III or IV, were also evaluated.",
    author = "Kenji Sasaki and Rouf, {Abu Shara S} and Takashi Hirota and Naoki Nakaya",
    year = "1999",
    language = "English",
    volume = "36",
    pages = "461--465",
    journal = "Journal of Heterocyclic Chemistry",
    issn = "0022-152X",
    publisher = "Heterocorporation",
    number = "2",

    }

    TY - JOUR

    T1 - Polycyclic N-heterocyclic compounds. 50 [1]. Synthesis and pharmacological evaluation of 2,3,6,7-tetrahydrothieno[2,3-h]- imidazo[2,1 - f] [1,6] naphthyridines, 3,4,7,8-tetrahydro-2H-thieno[2,3-h]pyrimido[2,1- f][1,6]naphthyridines and their precursor

    AU - Sasaki, Kenji

    AU - Rouf, Abu Shara S

    AU - Hirota, Takashi

    AU - Nakaya, Naoki

    PY - 1999

    Y1 - 1999

    N2 - Some novel 5-hydroxyalkylamino-1,2-dihydrothieno[2,3- h][1,6]naphthyridines were prepared by the reaction of 5-chloro-l,2- dihydrothieno[2,3-h][1,6]naphthyridine derivatives with some aminoalcohols in the presence of base. These derivatives were cyclized to the corresponding imidazo or pyrimido derivatives. The bronchodilatory activity of these compounds was evaluated on the basis of their relaxation activity to tracheal contraction induced by carbamylcholine chloride as a primary in vitro assays. Effect of some naphthyridines on carbamylcholine chloride-induced contractions of trachea in the presence or absence of milrinone or 4-(3- butoxy-4-methoxyphenyl)imidazolidin-2-one, which is inhibitor of phosphodiesterase III or IV, were also evaluated.

    AB - Some novel 5-hydroxyalkylamino-1,2-dihydrothieno[2,3- h][1,6]naphthyridines were prepared by the reaction of 5-chloro-l,2- dihydrothieno[2,3-h][1,6]naphthyridine derivatives with some aminoalcohols in the presence of base. These derivatives were cyclized to the corresponding imidazo or pyrimido derivatives. The bronchodilatory activity of these compounds was evaluated on the basis of their relaxation activity to tracheal contraction induced by carbamylcholine chloride as a primary in vitro assays. Effect of some naphthyridines on carbamylcholine chloride-induced contractions of trachea in the presence or absence of milrinone or 4-(3- butoxy-4-methoxyphenyl)imidazolidin-2-one, which is inhibitor of phosphodiesterase III or IV, were also evaluated.

    UR - http://www.scopus.com/inward/record.url?scp=0032949468&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0032949468&partnerID=8YFLogxK

    M3 - Article

    VL - 36

    SP - 461

    EP - 465

    JO - Journal of Heterocyclic Chemistry

    JF - Journal of Heterocyclic Chemistry

    SN - 0022-152X

    IS - 2

    ER -