Abstract
The first example of the unknown [1]benzoxepino[4,5-e]imidazo[1,2-c]pyrimidine ring system is demonstrated as a new class of potent anti-platelet aggregation agents. That is, the 1,2,4,5-tetrahydro-[1]benzoxepino[4,5-e]imidazo[1,2-c]pyrimidines 11a-c were prepared by ring closure of 4-(2-hydroxyalkylamino)-5,6-dihydro-[1]benzoxepino[5,4-d]pyrimidines 10a-c with phosphoryl chloride.
| Original language | English |
|---|---|
| Pages (from-to) | 303-306 |
| Number of pages | 4 |
| Journal | Synthesis |
| Issue number | 4 |
| Publication status | Published - Jan 1 1991 |
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry
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Nagamatsu, T., Tsurubayashi, S., Sasaki, K., & Hirota, T. (1991). Polycyclic N-hetero compounds; XXXIX: A facile synthesis of 1,2,4,5-Tetrahydro[1]benzoxepino[4,5-e]imidazo[1,2-c]pyrimidines via ring closure of 4-(2-hydroxyalkylamino)-5,6-dihydro-[1]benzoxepino[5,4-d]pyrimidines. Synthesis, (4), 303-306.