The first example of the unknown benzoxepino[4,5-e]imidazo[1,2-c]pyrimidine ring system is demonstrated as a new class of potent anti-platelet aggregation agents. That is, the 1,2,4,5-tetrahydro-benzoxepino[4,5-e]imidazo[1,2-c]pyrimidines 11a-c were prepared by ring closure of 4-(2-hydroxyalkylamino)-5,6-dihydro-benzoxepino[5,4-d]pyrimidines 10a-c with phosphoryl chloride.
|Number of pages||4|
|Publication status||Published - Jan 1 1991|
ASJC Scopus subject areas
- Organic Chemistry