Polycyclic N-hetero compounds; XXXIX: A facile synthesis of 1,2,4,5-Tetrahydro[1]benzoxepino[4,5-e]imidazo[1,2-c]pyrimidines via ring closure of 4-(2-hydroxyalkylamino)-5,6-dihydro-[1]benzoxepino[5,4-d]pyrimidines

T. Nagamatsu, S. Tsurubayashi, K. Sasaki, T. Hirota

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    The first example of the unknown [1]benzoxepino[4,5-e]imidazo[1,2-c]pyrimidine ring system is demonstrated as a new class of potent anti-platelet aggregation agents. That is, the 1,2,4,5-tetrahydro-[1]benzoxepino[4,5-e]imidazo[1,2-c]pyrimidines 11a-c were prepared by ring closure of 4-(2-hydroxyalkylamino)-5,6-dihydro-[1]benzoxepino[5,4-d]pyrimidines 10a-c with phosphoryl chloride.

    Original languageEnglish
    Pages (from-to)303-306
    Number of pages4
    JournalSynthesis
    Issue number4
    Publication statusPublished - Jan 1 1991

    ASJC Scopus subject areas

    • Catalysis
    • Organic Chemistry

    Fingerprint

    Dive into the research topics of 'Polycyclic N-hetero compounds; XXXIX: A facile synthesis of 1,2,4,5-Tetrahydro[1]benzoxepino[4,5-e]imidazo[1,2-c]pyrimidines via ring closure of 4-(2-hydroxyalkylamino)-5,6-dihydro-[1]benzoxepino[5,4-d]pyrimidines'. Together they form a unique fingerprint.

    Cite this