Polycyclic N-hetero compounds; XXXIX: A facile synthesis of 1,2,4,5-Tetrahydro[1]benzoxepino[4,5-e]imidazo[1,2-c]pyrimidines via ring closure of 4-(2-hydroxyalkylamino)-5,6-dihydro-[1]benzoxepino[5,4-d]pyrimidines

T. Nagamatsu, S. Tsurubayashi, K. Sasaki, T. Hirota

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The first example of the unknown [1]benzoxepino[4,5-e]imidazo[1,2-c]pyrimidine ring system is demonstrated as a new class of potent anti-platelet aggregation agents. That is, the 1,2,4,5-tetrahydro-[1]benzoxepino[4,5-e]imidazo[1,2-c]pyrimidines 11a-c were prepared by ring closure of 4-(2-hydroxyalkylamino)-5,6-dihydro-[1]benzoxepino[5,4-d]pyrimidines 10a-c with phosphoryl chloride.

Original languageEnglish
Pages (from-to)303-306
Number of pages4
JournalSynthesis
Issue number4
Publication statusPublished - Jan 1 1991

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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