Polycyclic N-hetero compounds. XXV. Synthesis of novel D-homo-11,13,15-triazasteroidal skeleton and investigation of its antidepressive activity

Takashi Hirota, Keiko Kawanishi, Kenji Sasaki

Research output: Contribution to journal › Article

12 Citations (Scopus)

Abstract

A synthesis of D-homo-11,13,15-triazasteroidal skeleton, corresponding to benzo[h]pyrimido[1,2-c]quinazoline as a novel ring system is described. Antidepressive activity of these compounds was screened by inhibitory action of reserpine-induced hypothermia. Compounds VIIc and XVI exhibited antireserpine action.

Original languageEnglish
Pages (from-to)1119-1130
Number of pages12
JournalHeterocycles
Volume24
Issue number4
Publication statusPublished - Apr 1 1986

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Hypothermia
Quinazolines
Induced Hypothermia
Reserpine
Skeleton

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Polycyclic N-hetero compounds. XXV. Synthesis of novel D-homo-11,13,15-triazasteroidal skeleton and investigation of its antidepressive activity. / Hirota, Takashi; Kawanishi, Keiko; Sasaki, Kenji.

In: Heterocycles, Vol. 24, No. 4, 01.04.1986, p. 1119-1130.

Research output: Contribution to journal › Article

Hirota, T, Kawanishi, K & Sasaki, K 1986, 'Polycyclic N-hetero compounds. XXV. Synthesis of novel D-homo-11,13,15-triazasteroidal skeleton and investigation of its antidepressive activity', Heterocycles, vol. 24, no. 4, pp. 1119-1130.
Hirota T, Kawanishi K, Sasaki K. Polycyclic N-hetero compounds. XXV. Synthesis of novel D-homo-11,13,15-triazasteroidal skeleton and investigation of its antidepressive activity. Heterocycles. 1986 Apr 1;24(4):1119-1130.
Hirota, Takashi ; Kawanishi, Keiko ; Sasaki, Kenji. / Polycyclic N-hetero compounds. XXV. Synthesis of novel D-homo-11,13,15-triazasteroidal skeleton and investigation of its antidepressive activity. In: Heterocycles. 1986 ; Vol. 24, No. 4. pp. 1119-1130.
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