Polycyclic N-hetero compounds. XXV. Synthesis of novel D-homo-11,13,15-triazasteroidal skeleton and investigation of its antidepressive activity

Takashi Hirota, Keiko Kawanishi, Kenji Sasaki

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)

    Abstract

    A synthesis of D-homo-11,13,15-triazasteroidal skeleton, corresponding to benzo[h]pyrimido[1,2-c]quinazoline as a novel ring system is described. Antidepressive activity of these compounds was screened by inhibitory action of reserpine-induced hypothermia. Compounds VIIc and XVI exhibited antireserpine action.

    Original languageEnglish
    Pages (from-to)1119-1130
    Number of pages12
    JournalHeterocycles
    Volume24
    Issue number4
    DOIs
    Publication statusPublished - Apr 1 1986

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Pharmacology
    • Organic Chemistry

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