Polycyclic N-hetero compounds. XXV. Synthesis of novel D-homo-11,13,15-triazasteroidal skeleton and investigation of its antidepressive activity

Takashi Hirota, Keiko Kawanishi, Kenji Sasaki

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A synthesis of D-homo-11,13,15-triazasteroidal skeleton, corresponding to benzo[h]pyrimido[1,2-c]quinazoline as a novel ring system is described. Antidepressive activity of these compounds was screened by inhibitory action of reserpine-induced hypothermia. Compounds VIIc and XVI exhibited antireserpine action.

Original languageEnglish
Pages (from-to)1119-1130
Number of pages12
JournalHeterocycles
Volume24
Issue number4
DOIs
Publication statusPublished - Apr 1 1986

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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