Polycyclic N-hetero compounds. XXV. Synthesis of novel D-homo-11,13,15-triazasteroidal skeleton and investigation of its antidepressive activity

Takashi Hirota; Keiko Kawanishi; Kenji Sasaki

doi:10.3987/R-1986-04-1119

Polycyclic N-hetero compounds. XXV. Synthesis of novel D-homo-11,13,15-triazasteroidal skeleton and investigation of its antidepressive activity

Takashi Hirota, Keiko Kawanishi, Kenji Sasaki

Institute for Education and Student Services

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

A synthesis of D-homo-11,13,15-triazasteroidal skeleton, corresponding to benzo[h]pyrimido[1,2-c]quinazoline as a novel ring system is described. Antidepressive activity of these compounds was screened by inhibitory action of reserpine-induced hypothermia. Compounds VIIc and XVI exhibited antireserpine action.

Original language	English
Pages (from-to)	1119-1130
Number of pages	12
Journal	Heterocycles
Volume	24
Issue number	4
DOIs	https://doi.org/10.3987/R-1986-04-1119
Publication status	Published - Apr 1 1986

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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abstract = "A synthesis of D-homo-11,13,15-triazasteroidal skeleton, corresponding to benzo[h]pyrimido[1,2-c]quinazoline as a novel ring system is described. Antidepressive activity of these compounds was screened by inhibitory action of reserpine-induced hypothermia. Compounds VIIc and XVI exhibited antireserpine action.",

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AU - Sasaki, Kenji

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AB - A synthesis of D-homo-11,13,15-triazasteroidal skeleton, corresponding to benzo[h]pyrimido[1,2-c]quinazoline as a novel ring system is described. Antidepressive activity of these compounds was screened by inhibitory action of reserpine-induced hypothermia. Compounds VIIc and XVI exhibited antireserpine action.

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