Polycyclic N-Hetero Compounds. XXIII. Synthesis and Antidepressive Activity of 4-Substituted 5,6-Dihydrobenzo[h]quinazolines

Takashi Hirota, Keiko Kawanishi, Kenji Sasaki, Tetsuto Namba

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4-Alkylamino-5,6-dihydrobenzo[h]quinazolines (IIIa—k) were synthesized by the reaction of 4-chloro-5,6-dihydrobenzo[h]quinazoline (IIc) with primary alkylamines. Screening of 4-amino-(IIa), 4-hydroxy- (IIb), and 4-(2-hydroxyethylamino)-5,6-dihydrobenzo[h]quinazoline (lid), as well as IIc and IIIa—k, for antireserpine action indicated that lid, IIIa, and IIIh exhibited effective antidepressant activity.

Original languageEnglish
Pages (from-to)3011-3014
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Issue number7
Publication statusPublished - Jan 1 1986



  • 4-alkylaminobenzo[h]quinazoline
  • antidepressive activity
  • antireserpine activity
  • benzo[h]quinazoline
  • primary alkylamine

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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