Polycyclic N-hetero compounds. XXI. Synthesis of novel ring system, 4H-imidazo [1′ 2′: 1,6]pyrimido [5,4-d][1]benzazepine as B-homo-6,11,13,15-tetraazasteroidal analogue

Takashi Hirota, Masami Fukumoto, Kenji Sasaki, Tetsuto Namba, Shohei Hayakawa

Research output: Contribution to journalArticle

Abstract

A synthesis of 4H-imidazo [1′,2′: 1,6]pyrimido-[5,4-d] [1]benzazepine (XIIIa) having a novel ring system is described. Methyl anthranilate (IVa) was converted to 4-(2-hydroxyethylamino)-6,7-dihydro-5H-pyrimido [5,4-d][1]-benzazepine (XIa) in several steps and XIa was cyclized to XIIIa. A synthesis of 8-chloro derivative of XIIIa is also described.

Original languageEnglish
Pages (from-to)143-154
Number of pages12
JournalHeterocycles
Volume24
Issue number1
DOIs
Publication statusPublished - Jan 1 1986

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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