Polycyclic N-hetero compounds. XXI. Synthesis of novel ring system, 4H-imidazo [1′ 2′: 1,6]pyrimido [5,4-d][1]benzazepine as B-homo-6,11,13,15-tetraazasteroidal analogue

Takashi Hirota; Masami Fukumoto; Kenji Sasaki; Tetsuto Namba; Shohei Hayakawa

doi:10.3987/R-1986-01-0143

Polycyclic N-hetero compounds. XXI. Synthesis of novel ring system, 4H-imidazo [1′ 2′: 1,6]pyrimido [5,4-d][1]benzazepine as B-homo-6,11,13,15-tetraazasteroidal analogue

Takashi Hirota, Masami Fukumoto, Kenji Sasaki, Tetsuto Namba, Shohei Hayakawa

Institute for Education and Student Services

Research output: Contribution to journal › Article › peer-review

Abstract

A synthesis of 4H-imidazo [1′,2′: 1,6]pyrimido-[5,4-d] [1]benzazepine (XIIIa) having a novel ring system is described. Methyl anthranilate (IVa) was converted to 4-(2-hydroxyethylamino)-6,7-dihydro-5H-pyrimido [5,4-d][1]-benzazepine (XIa) in several steps and XIa was cyclized to XIIIa. A synthesis of 8-chloro derivative of XIIIa is also described.

Original language	English
Pages (from-to)	143-154
Number of pages	12
Journal	Heterocycles
Volume	24
Issue number	1
DOIs	https://doi.org/10.3987/R-1986-01-0143
Publication status	Published - Jan 1 1986

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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Polycyclic N-hetero compounds. XXI. Synthesis of novel ring system, 4H-imidazo [1′ 2′ : 1,6]pyrimido [5,4-d][1]benzazepine as B-homo-6,11,13,15-tetraazasteroidal analogue. / Hirota, Takashi; Fukumoto, Masami; Sasaki, Kenji; Namba, Tetsuto; Hayakawa, Shohei.

In: Heterocycles, Vol. 24, No. 1, 01.01.1986, p. 143-154.

Research output: Contribution to journal › Article › peer-review

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