Polycyclic N-Hetero Compounds. XVII.1) Reactions of Heterocyclic Active Methyl Group with Formamide or Trisformylaminomethane

Takashi Hirota, Takaji Koyama, Chizuko Basho, Tetsuto Nanba, Kenji Sasaki, Masatoshi Yamato

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Pyrimidine formation from active methyl group on heterocycles is described. 2-Methyl-pyridine (I), -quinoline (III), -pyrazine (IX), -benzothiazole (XX), 2,4-dimethyl-quinoline (VII), and -thiazole (XIII) were successful in pyrimidine formation. 2-Methyl-imidazole (XI), -benzimidazole (XV), -benzoxazole (XVI), and 2,4-dimethyloxazole (XII) were unsuccessful. Compound (III) gave pyrazine (V) and pyridine (VI) derivatives and pyridine formation occurred also in XX.

Original languageEnglish
Pages (from-to)3056-3060
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Issue number11
Publication statusPublished - 1977


  • azoles
  • formamide
  • heterocyclic active methyl group
  • pyrazine
  • pyrazine formation
  • pyridine
  • pyridine formation
  • pyrimidine formation
  • trisformylaminomethane

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery


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