Polycyclic N-hetero compounds. XLII

Convenient syntheses of 6,7-dihydro-5H-pyrido[2,3-b]pyrimido[4,5-d]azepine as a novel polyheterocyclic ring system and its 4-substituted derivatives

T. Nagamatsu, Y. Hantani, M. Takaishi, Kenji Sasaki, T. Hirota

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A convenient synthetic route for the syntheses of 6,7-dihydro-5H-pyrido[2,3-6]pyrimido[4,5-d]azepine and its 4-substituted derivatives starting from ethyl 2-aminopyridine-3-carboxylate is described as the fist example of the unknown ring system. A new class of anti-platelet aggregation activity for them against collagene-induced aggregation of rabbit blood platelet in vitro was found.

Original languageEnglish
Pages (from-to)942-946
Number of pages5
JournalSynthesis
Issue number11
Publication statusPublished - 1991

Fingerprint

Azepines
Platelets
Agglomeration
Derivatives
Blood

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

@article{5bc405cf5388457ead11cc3574823a51,
title = "Polycyclic N-hetero compounds. XLII: Convenient syntheses of 6,7-dihydro-5H-pyrido[2,3-b]pyrimido[4,5-d]azepine as a novel polyheterocyclic ring system and its 4-substituted derivatives",
abstract = "A convenient synthetic route for the syntheses of 6,7-dihydro-5H-pyrido[2,3-6]pyrimido[4,5-d]azepine and its 4-substituted derivatives starting from ethyl 2-aminopyridine-3-carboxylate is described as the fist example of the unknown ring system. A new class of anti-platelet aggregation activity for them against collagene-induced aggregation of rabbit blood platelet in vitro was found.",
author = "T. Nagamatsu and Y. Hantani and M. Takaishi and Kenji Sasaki and T. Hirota",
year = "1991",
language = "English",
pages = "942--946",
journal = "Synthesis",
issn = "0039-7881",
publisher = "Georg Thieme Verlag",
number = "11",

}

TY - JOUR

T1 - Polycyclic N-hetero compounds. XLII

T2 - Convenient syntheses of 6,7-dihydro-5H-pyrido[2,3-b]pyrimido[4,5-d]azepine as a novel polyheterocyclic ring system and its 4-substituted derivatives

AU - Nagamatsu, T.

AU - Hantani, Y.

AU - Takaishi, M.

AU - Sasaki, Kenji

AU - Hirota, T.

PY - 1991

Y1 - 1991

N2 - A convenient synthetic route for the syntheses of 6,7-dihydro-5H-pyrido[2,3-6]pyrimido[4,5-d]azepine and its 4-substituted derivatives starting from ethyl 2-aminopyridine-3-carboxylate is described as the fist example of the unknown ring system. A new class of anti-platelet aggregation activity for them against collagene-induced aggregation of rabbit blood platelet in vitro was found.

AB - A convenient synthetic route for the syntheses of 6,7-dihydro-5H-pyrido[2,3-6]pyrimido[4,5-d]azepine and its 4-substituted derivatives starting from ethyl 2-aminopyridine-3-carboxylate is described as the fist example of the unknown ring system. A new class of anti-platelet aggregation activity for them against collagene-induced aggregation of rabbit blood platelet in vitro was found.

UR - http://www.scopus.com/inward/record.url?scp=0025948461&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025948461&partnerID=8YFLogxK

M3 - Article

SP - 942

EP - 946

JO - Synthesis

JF - Synthesis

SN - 0039-7881

IS - 11

ER -