Polycyclic N-hetero compounds. XLII: Convenient syntheses of 6,7-dihydro-5H-pyrido[2,3-b]pyrimido[4,5-d]azepine as a novel polyheterocyclic ring system and its 4-substituted derivatives

T. Nagamatsu, Y. Hantani, M. Takaishi, K. Sasaki, T. Hirota

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A convenient synthetic route for the syntheses of 6,7-dihydro-5H-pyrido[2,3-6]pyrimido[4,5-d]azepine and its 4-substituted derivatives starting from ethyl 2-aminopyridine-3-carboxylate is described as the fist example of the unknown ring system. A new class of anti-platelet aggregation activity for them against collagene-induced aggregation of rabbit blood platelet in vitro was found.

Original languageEnglish
Pages (from-to)942-946
Number of pages5
JournalSynthesis
Issue number11
DOIs
Publication statusPublished - Jan 1 1991

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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