Polyarteritis nodosa with marked eosinophilia, associated with severe gastrointestinal tract involvement and recurrent venous thrombosis

Hiroshi Oiwa, Kohei Taniguchi, Natsuki Miyoshi, Keiko Sasaki, Kouichi Ichimura, Tetsushi Kubota, Daisuke Sato

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A 45-year-old man was admitted with acute abdominal pain and eosinophilia. Abdominal computed tomography revealed thickness of the ascending and transverse colon with decreased contrast enhancement and a small amount of ascites. In an emergency operation, the necrotic colon was resected. Histopathology showed subserous medium-sized arteritis with abundant eosinophil infiltrates and thrombosis in the portal vein branches. He was diagnosed with polyarteritis nodosa (PAN), and immunosuppressive therapy improved his condition. Two years later, the disease recurred with ischemic cutaneous lesions and marked eosinophilia. Our experience suggests that marked eosinophilia in PAN may imply severe organ involvement, including gastrointestinal necrosis, as well as the association of venous thrombosis.

Original languageEnglish
Pages (from-to)3051-3055
Number of pages5
JournalInternal Medicine
Volume58
Issue number20
DOIs
Publication statusPublished - 2019

Keywords

  • Acute surgical abdomen
  • Colon
  • Eosinophilia
  • Hypereosinophilic syndrome
  • Medium-sized vasculitis
  • Polyarteritis nodosa

ASJC Scopus subject areas

  • Internal Medicine

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