Pneumocystis pneumonia concomitant with ectopic ACTH syndrome caused by a large cell neuroendocrine carcinoma of the thymus

Naohiro Oda, Nobuaki Miyahara, Masahiro Tabata, Daisuke Minami, Kiichiro Ninomiya, Arihiko Kanehiro, Motoshi Komatsubara, Kenichi Inagaki, Mitsune Tanimoto, Katsuyuki Kiura

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We herein report the case of a 44-year-old man who was diagnosed with pneumocystis pneumonia (PCP) concomitant with ectopic adrenocorticotropic hormone (ACTH) syndrome, which had been caused by a large cell neuroendocrine carcinoma of the thymus. Chest computed tomography revealed ground-glass opacities in the lungs. PCP was diagnosed by a polymerase chain reaction with bronchoalveolar lavage. The levels of cortisol were slowly corrected with an adrenal enzyme inhibitor, and the exacerbation of PCP was successfully avoided. Our case indicates that in addition to prophylaxis, the early diagnosis of PCP and the slow correction of hypercortisolemia should be considered in order to prevent an exacerbation due to the reconstitution of the immune function in patients with ectopic ACTH syndrome.

Original languageEnglish
Pages (from-to)551-555
Number of pages5
JournalInternal Medicine
Volume56
Issue number5
DOIs
Publication statusPublished - 2017

Fingerprint

Paraneoplastic Endocrine Syndromes
Neuroendocrine Carcinoma
Large Cell Carcinoma
Pneumocystis Pneumonia
Adrenocorticotropic Hormone
Thymus Gland
Bronchoalveolar Lavage
Enzyme Inhibitors
Glass
Hydrocortisone
Early Diagnosis
Thorax
Tomography
Polymerase Chain Reaction
Lung

Keywords

  • Cushing’s syndrome
  • Ectopic ACTH syndrome
  • Large cell neuroendocrine carcinoma
  • Neuroendocrine tumor
  • Pneumocystis pneumonia
  • Thymus

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Pneumocystis pneumonia concomitant with ectopic ACTH syndrome caused by a large cell neuroendocrine carcinoma of the thymus. / Oda, Naohiro; Miyahara, Nobuaki; Tabata, Masahiro; Minami, Daisuke; Ninomiya, Kiichiro; Kanehiro, Arihiko; Komatsubara, Motoshi; Inagaki, Kenichi; Tanimoto, Mitsune; Kiura, Katsuyuki.

In: Internal Medicine, Vol. 56, No. 5, 2017, p. 551-555.

Research output: Contribution to journalArticle

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AU - Ninomiya, Kiichiro

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