@article{ba7394f0e8504576b675154015c8f644,
title = "PlexinD1 signaling controls morphological changes and migration termination in newborn neurons",
abstract = "Newborn neurons maintain a very simple, bipolar shape, while they migrate from their birthplace toward their destinations in the brain, where they differentiate into mature neurons with complex dendritic morphologies. Here, we report a mechanism by which the termination of neuronal migration is maintained in the postnatal olfactory bulb (OB). During neuronal deceleration in the OB, newborn neurons transiently extend a protrusion from the proximal part of their leading process in the resting phase, which we refer to as a filopodium-like lateral protrusion (FLP). The FLP formation is induced by PlexinD1 downregulation and local Rac1 activation, which coincide with microtubule reorganization and the pausing of somal translocation. The somal translocation of resting neurons is suppressed by microtubule polymerization within the FLP. The timing of neuronal migration termination, controlled by Sema3E-PlexinD1-Rac1 signaling, influences the final positioning, dendritic patterns, and functions of the neurons in the OB. These results suggest that PlexinD1 signaling controls FLP formation and the termination of neuronal migration through a precise control of microtubule dynamics.",
keywords = "microtubule, neuronal migration, olfactory bulb, photoactivation, postnatal neurogenesis",
author = "Masato Sawada and Nobuhiko Ohno and Mitsuyasu Kawaguchi and Huang, {Shih Hui} and Takao Hikita and Youmei Sakurai and {Bang Nguyen}, Huy and {Quynh Thai}, Truc and Yuri Ishido and Yutaka Yoshida and Hidehiko Nakagawa and Akiyoshi Uemura and Kazunobu Sawamoto",
note = "Funding Information: We thank M. Kengaku and T. Kawauchi for critical reading of the manuscript; F. Mann, C. E. Henderson, M. Yamaguchi, S. Itohara, T. Ikeda, R. Kageyama, M. G{\"o}tz, H. Miyoshi, T. Toyofuku, I. Oinuma, M. Matsuda, D. J. Solecki, W. Bement, K. Hahn, K. Kaibuchi, K. Yoshikawa, M. Hattori, and the MMRRC for materials; H. Takase, T. Miyamoto, I. Miyoshi, N. Dohi, K. Ikenaka, M. Furuse, M. Takahashi, and M. Takagishi for technical support; and J.M. Garc{\'i}a-Verdugo, V. Herranz-P{\'e}rez, A. Cebri{\'a}n-Silla, and Sawamoto laboratory members for discussions. This work was supported by research grants from NEXT (LS104), MEXT KAKENHI (22122004, 17H05750, and 17H05512) (to K.S.), JSPS KAKENHI (26250019, 17H01392, and JP16H06280 [to K.S.], 25890017, and 26830014 [to M.S.]), JSPS Program for Advancing Strategic International Networks to Accelerate the Circulation of Talented Researchers (S2704 [to M.S., M.K., H.N., and K.S.]), Grant-in-Aid for Research at Nagoya City University (to K.S. and H.N.), NIH grants NS093002 (to Y.Y.), the Novartis Foundation (Japan) for the Promotion of Science, the Hori Sciences and Arts Foundation (to M.S.), the Takeda Science Foundation (to K.S. and M.S.), and the Cooperative Study Programs of National Institute for Physiological Sciences (to K.S.). Funding Information: We thank M. Kengaku and T. Kawauchi for critical reading of the manuscript; F. Mann, C. E. Henderson, M. Yamaguchi, S. Itohara, T. Ikeda, R. Kageyama, M. G?tz, H. Miyoshi, T. Toyofuku, I. Oinuma, M. Matsuda, D. J. Solecki, W. Bement, K. Hahn, K. Kaibuchi, K. Yoshikawa, M. Hattori, and the MMRRC for materials; H. Takase, T. Miyamoto, I. Miyoshi, N. Dohi, K. Ikenaka, M. Furuse, M. Takahashi, and M. Takagishi for technical support; and J.M. Garc?a-Verdugo, V. Herranz-P?rez, A. Cebri?n-Silla, and Sawamoto laboratory members for discussions. This work was supported by research grants from NEXT (LS104), MEXT KAKENHI (22122004, 17H05750, and 17H05512) (to K.S.), JSPS KAKENHI (26250019, 17H01392, and JP16H06280 [to K.S.], 25890017, and 26830014 [to M.S.]), JSPS Program for Advancing Strategic International Networks to Accelerate the Circulation of Talented Researchers (S2704 [to M.S., M.K., H.N., and K.S.]), Grant-in-Aid for Research at Nagoya City University (to K.S. and H.N.), NIH grants NS093002 (to Y.Y.), the Novartis Foundation (Japan) for the Promotion of Science, the Hori Sciences and Arts Foundation (to M.S.), the Takeda Science Foundation (to K.S. and M.S.), and the Cooperative Study Programs of National Institute for Physiological Sciences (to K.S.). Publisher Copyright: {\textcopyright} 2018 The Authors",
year = "2018",
month = feb,
day = "15",
doi = "10.15252/embj.201797404",
language = "English",
volume = "37",
journal = "EMBO Journal",
issn = "0261-4189",
publisher = "Nature Publishing Group",
number = "4",
}