Platypnea-orthodeoxia syndrome induced by multiple vertebral compression fractures and an atrial septal defect

Research output: Contribution to journalArticle

Abstract

Platypnea-orthodeoxia syndrome (POS) is a rare condition that is characterized by dyspnea and arterial oxygen desaturation, which worsen on standing and which are relieved by recumbency. We treated an 80-year-old woman with an atrial septal defect (ASD) who demonstrated POS following thoracic and lumbar vertebral compression fractures. The surgical closure of the ASD relieved her symptoms. The etiology might have been multiple compression fractures causing kyphosis and aortic distortion producing right atrial compression and increased right-to-left flow through the ASD. POS should be considered in the differential diagnosis of patients who develop dyspnea after vertebral compression fractures. The careful assessment of the patient’s history and clinical condition helps in the diagnosis of POS.

Original languageEnglish
Pages (from-to)971-973
Number of pages3
JournalInternal Medicine
Volume57
Issue number7
DOIs
Publication statusPublished - Jan 1 2018

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Compression Fractures
Atrial Heart Septal Defects
Dyspnea
Kyphosis
Differential Diagnosis
Thorax
Oxygen

Keywords

  • Atrial septal defect
  • Platypnea-orthodeoxia syndrome
  • Vertebral fracture

ASJC Scopus subject areas

  • Internal Medicine

Cite this

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title = "Platypnea-orthodeoxia syndrome induced by multiple vertebral compression fractures and an atrial septal defect",
abstract = "Platypnea-orthodeoxia syndrome (POS) is a rare condition that is characterized by dyspnea and arterial oxygen desaturation, which worsen on standing and which are relieved by recumbency. We treated an 80-year-old woman with an atrial septal defect (ASD) who demonstrated POS following thoracic and lumbar vertebral compression fractures. The surgical closure of the ASD relieved her symptoms. The etiology might have been multiple compression fractures causing kyphosis and aortic distortion producing right atrial compression and increased right-to-left flow through the ASD. POS should be considered in the differential diagnosis of patients who develop dyspnea after vertebral compression fractures. The careful assessment of the patient’s history and clinical condition helps in the diagnosis of POS.",
keywords = "Atrial septal defect, Platypnea-orthodeoxia syndrome, Vertebral fracture",
author = "Ko Harada and Koji Nakagawa and Hiroaki Ohtsuka and Yoichi Takaya and Teiji Akagi and Kazufumi Nakamura and Hiroshi Morita and Hiroshi Itoh",
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T1 - Platypnea-orthodeoxia syndrome induced by multiple vertebral compression fractures and an atrial septal defect

AU - Harada, Ko

AU - Nakagawa, Koji

AU - Ohtsuka, Hiroaki

AU - Takaya, Yoichi

AU - Akagi, Teiji

AU - Nakamura, Kazufumi

AU - Morita, Hiroshi

AU - Itoh, Hiroshi

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Platypnea-orthodeoxia syndrome (POS) is a rare condition that is characterized by dyspnea and arterial oxygen desaturation, which worsen on standing and which are relieved by recumbency. We treated an 80-year-old woman with an atrial septal defect (ASD) who demonstrated POS following thoracic and lumbar vertebral compression fractures. The surgical closure of the ASD relieved her symptoms. The etiology might have been multiple compression fractures causing kyphosis and aortic distortion producing right atrial compression and increased right-to-left flow through the ASD. POS should be considered in the differential diagnosis of patients who develop dyspnea after vertebral compression fractures. The careful assessment of the patient’s history and clinical condition helps in the diagnosis of POS.

AB - Platypnea-orthodeoxia syndrome (POS) is a rare condition that is characterized by dyspnea and arterial oxygen desaturation, which worsen on standing and which are relieved by recumbency. We treated an 80-year-old woman with an atrial septal defect (ASD) who demonstrated POS following thoracic and lumbar vertebral compression fractures. The surgical closure of the ASD relieved her symptoms. The etiology might have been multiple compression fractures causing kyphosis and aortic distortion producing right atrial compression and increased right-to-left flow through the ASD. POS should be considered in the differential diagnosis of patients who develop dyspnea after vertebral compression fractures. The careful assessment of the patient’s history and clinical condition helps in the diagnosis of POS.

KW - Atrial septal defect

KW - Platypnea-orthodeoxia syndrome

KW - Vertebral fracture

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