Platelet-derived endothelial cell growth factor is not implicated in progression of cervical cancer.

J. Kodama, N. Seki, K. Tokumo, A. Hongo, Y. Miyagi, M. Yoshinouchi, H. Okuda, T. Kudo

Research output: Contribution to journalArticle

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Abstract

We examined the expression of platelet-derived endothelial cell growth factor (PD-ECGF) mRNAs in 47 invasive cervical cancer tissues by semi-quantitative RT-PCR and addressed its association with clinicopathological features including microvessel density. Squamous cell carcinomas expressed higher levels of PD-ECGF mRNA than non-squamous cell carcinomas (P=0.014). We found no association between FIGO stage and levels of PD-ECGF mRNA. A subset of 31 patients with stage Ib-II cervical cancer underwent radical hysterectomy and pelvic lymphadenectomy. There were no significant differences in PD-ECGF mRNA levels with respect to tumor size, degree of stromal invasion, lymphvascular space involvement, parametrial involvement, vaginal involvement or lymph node metastasis among these patients. There was no correlation between microvessel density and the levels of PD-ECGF mRNA. These findings suggest that PD-ECGF expression is not associated with progression and metastasis of cervical cancer.

Original languageEnglish
Pages (from-to)617-620
Number of pages4
JournalOncology Reports
Volume6
Issue number3
Publication statusPublished - May 1999

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Thymidine Phosphorylase
Uterine Cervical Neoplasms
Messenger RNA
Microvessels
Neoplasm Metastasis
Lymph Node Excision
Hysterectomy
Squamous Cell Carcinoma
Lymph Nodes
Carcinoma
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Kodama, J., Seki, N., Tokumo, K., Hongo, A., Miyagi, Y., Yoshinouchi, M., ... Kudo, T. (1999). Platelet-derived endothelial cell growth factor is not implicated in progression of cervical cancer. Oncology Reports, 6(3), 617-620.

Platelet-derived endothelial cell growth factor is not implicated in progression of cervical cancer. / Kodama, J.; Seki, N.; Tokumo, K.; Hongo, A.; Miyagi, Y.; Yoshinouchi, M.; Okuda, H.; Kudo, T.

In: Oncology Reports, Vol. 6, No. 3, 05.1999, p. 617-620.

Research output: Contribution to journalArticle

Kodama, J, Seki, N, Tokumo, K, Hongo, A, Miyagi, Y, Yoshinouchi, M, Okuda, H & Kudo, T 1999, 'Platelet-derived endothelial cell growth factor is not implicated in progression of cervical cancer.', Oncology Reports, vol. 6, no. 3, pp. 617-620.
Kodama J, Seki N, Tokumo K, Hongo A, Miyagi Y, Yoshinouchi M et al. Platelet-derived endothelial cell growth factor is not implicated in progression of cervical cancer. Oncology Reports. 1999 May;6(3):617-620.
Kodama, J. ; Seki, N. ; Tokumo, K. ; Hongo, A. ; Miyagi, Y. ; Yoshinouchi, M. ; Okuda, H. ; Kudo, T. / Platelet-derived endothelial cell growth factor is not implicated in progression of cervical cancer. In: Oncology Reports. 1999 ; Vol. 6, No. 3. pp. 617-620.
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