Platelet aggregation induced by uncommon serotypes of Streptococcus sanguis isolated from patients with Behçet's disease

Emiko Isogai, Hiroshi Isogai, Kenji Yokota, Shunji Hayashi, Nobuhiro Fujii, Keiji Oguma, Koji Yoshikawa, Yoichi Sasamoto, Satoshi Kotake, Shigeaki Ohno

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Uncommon serotypes were tested for their ability to induce aggregation in platelet-rich plasma. Both uncommon and common serotypes induced platelet aggregation in rabbit platelet-rich plasma, but serotonin release was higher with the uncommon serotypes. Aggregation at ATP release varied between uncommon and common serotypes. With human platelet-rich plasma, only uncommon serotypes showed aggregation. Differences in serotype selectivity and the rate of aggregation were noted among platelet donors. About half of the patients with Behçet's disease and 30% of health controls showed platelet aggregation. Plasma from non-responder patients with Behçet's disease inhibited aggregation of healthy responder platelets within 20 min. Thus selective binding of uncommon serotypes of Strep. sanguis to plateletes might cause the vasculitis in Behçet's disease.

Original languageEnglish
Pages (from-to)425-429
Number of pages5
JournalArchives of Oral Biology
Volume36
Issue number6
DOIs
Publication statusPublished - 1991
Externally publishedYes

Fingerprint

Streptococcus sanguis
Platelet Aggregation
Platelet-Rich Plasma
Blood Platelets
Vasculitis
Serogroup
Serotonin
Adenosine Triphosphate
Tissue Donors
Rabbits
Health

Keywords

  • Behçet's disease
  • platelet
  • uncommon serotypes of Streptococcus sanguis

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology

Cite this

Platelet aggregation induced by uncommon serotypes of Streptococcus sanguis isolated from patients with Behçet's disease. / Isogai, Emiko; Isogai, Hiroshi; Yokota, Kenji; Hayashi, Shunji; Fujii, Nobuhiro; Oguma, Keiji; Yoshikawa, Koji; Sasamoto, Yoichi; Kotake, Satoshi; Ohno, Shigeaki.

In: Archives of Oral Biology, Vol. 36, No. 6, 1991, p. 425-429.

Research output: Contribution to journalArticle

Isogai, E, Isogai, H, Yokota, K, Hayashi, S, Fujii, N, Oguma, K, Yoshikawa, K, Sasamoto, Y, Kotake, S & Ohno, S 1991, 'Platelet aggregation induced by uncommon serotypes of Streptococcus sanguis isolated from patients with Behçet's disease', Archives of Oral Biology, vol. 36, no. 6, pp. 425-429. https://doi.org/10.1016/0003-9969(91)90132-E
Isogai, Emiko ; Isogai, Hiroshi ; Yokota, Kenji ; Hayashi, Shunji ; Fujii, Nobuhiro ; Oguma, Keiji ; Yoshikawa, Koji ; Sasamoto, Yoichi ; Kotake, Satoshi ; Ohno, Shigeaki. / Platelet aggregation induced by uncommon serotypes of Streptococcus sanguis isolated from patients with Behçet's disease. In: Archives of Oral Biology. 1991 ; Vol. 36, No. 6. pp. 425-429.
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