Platelet adhesion on titanium oxide gels

Effect of surface oxidation

Shinji Takemoto, Tatsuhiro Yamamoto, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka, Seisuke Takashima

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

The correlations between titanium oxide layers on oxidized titanium (Ti) substrates and platelet adhesion were examined. Ti substrates were prepared by three different oxidation methods: the first one was treated with hydrogen peroxide (H2O2) solution, the second one was heated in air at moderate temperatures, and the third one was processed with both H 2O2 and heating. The titanium oxide layers formed on the Ti substrates were characterized by wettability, chemical composition, thickness, and crystal phase. The platelet adhesion on these oxide layers was examined and correlated to the characterizations of the surface layers. The number of adhesive platelets seemingly correlated with the contact angle towards distilled water, because the number increased close to 70-80° of the contact angle. The effect of surface oxidation on platelet adhesion was examined in detail and it was found that the composition and thickness of the oxide layer influenced platelet adhesion rather than wettability. Thick titanium oxide layers formed on Ti substrates by heating displayed less platelet adhesion than thin oxide layers on untreated Ti substrates. The largest number of adhesive platelets was found on H2O 2-oxidized substrates; the substrates found on amorphous titanium oxide contained the Ti-peroxide radical species. The number of platelets, on the other hand, could hardly be observed on Ti substrates treated with H 2O2 and subsequently heated above 300°C. The titanium oxide layer on the substrate was thick and we found it to consist of only a few radical species. That is, the effect of heat treatment accelerates the growth of the oxide layer, and decomposes or decreases the number of radical species. Ti substrates with H2O2 and heat treatment above 300°C held the least number of platelets, and were concluded to be the most inhibitory for platelet adhesion.

Original languageEnglish
Pages (from-to)3485-3492
Number of pages8
JournalBiomaterials
Volume25
Issue number17
DOIs
Publication statusPublished - Aug 2004

Fingerprint

Titanium oxides
Platelets
Titanium
Blood Platelets
Adhesion
Gels
Oxidation
Substrates
Platelet Count
Oxides
Wettability
Adhesives
Heating
Hot Temperature
Contact angle
Wetting
Heat treatment
titanium dioxide
Peroxides
Hydrogen Peroxide

Keywords

  • Blood compatibility
  • Peroxide gel
  • Platelet adhesion
  • Surface oxidation
  • Titanium

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Cite this

Takemoto, S., Yamamoto, T., Tsuru, K., Hayakawa, S., Osaka, A., & Takashima, S. (2004). Platelet adhesion on titanium oxide gels: Effect of surface oxidation. Biomaterials, 25(17), 3485-3492. https://doi.org/10.1016/j.biomaterials.2003.10.070

Platelet adhesion on titanium oxide gels : Effect of surface oxidation. / Takemoto, Shinji; Yamamoto, Tatsuhiro; Tsuru, Kanji; Hayakawa, Satoshi; Osaka, Akiyoshi; Takashima, Seisuke.

In: Biomaterials, Vol. 25, No. 17, 08.2004, p. 3485-3492.

Research output: Contribution to journalArticle

Takemoto, S, Yamamoto, T, Tsuru, K, Hayakawa, S, Osaka, A & Takashima, S 2004, 'Platelet adhesion on titanium oxide gels: Effect of surface oxidation', Biomaterials, vol. 25, no. 17, pp. 3485-3492. https://doi.org/10.1016/j.biomaterials.2003.10.070
Takemoto, Shinji ; Yamamoto, Tatsuhiro ; Tsuru, Kanji ; Hayakawa, Satoshi ; Osaka, Akiyoshi ; Takashima, Seisuke. / Platelet adhesion on titanium oxide gels : Effect of surface oxidation. In: Biomaterials. 2004 ; Vol. 25, No. 17. pp. 3485-3492.
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