Plasma urea and ammonia in epileptic patients and their relatives

Najma A. Janjua, Toshifumi Itano, Toshiaki Kugoh, Kiyoshi Hosokawa, Hideki Matsui, Masaaki Tokuda, Osamu Hatase

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


The plasma levels of urea and ammonia were examined in patients with primary generalized epilepsy, patients with partial epilepsy and in the first-degree relatives of these subjects. The results show a significant decrease in plasma urea in both groups of patients and their first-degree relatives as compared to the non-epileptic controls. The plasma ammonia concentrations were significantly higher in both groups of patients and in the relatives of generalized epilepsy patients as compared to the controls. The observed changes in plasma urea and ammonia were found not to be due to the effect of anticonvulsant drugs. The data suggest that a metabolic defect in urea synthesis may constitute one of the genetic components in the multifactorial etiologies of primary generalized and partial epilepsies.

Original languageEnglish
Pages (from-to)239-244
Number of pages6
JournalEpilepsy Research
Issue number3
Publication statusPublished - Dec 1992


  • Ammonia
  • Metabolic defect, genetic
  • Plasma
  • Urea

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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