Plasma stromal cell-derived factor-1 during granulocyte colony-stimulating factor-induced peripheral blood stem cell mobilization

T. Kozuka, F. Ishimaru, K. Fujii, K. Masuda, K. Kaneda, T. Imai, N. Fujii, H. Ishikura, S. Hongo, T. Watanabe, K. Shinagawa, K. Ikeda, K. Niiya, M. Harada, M. Tanimoto

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

In this report, we examined plasma stromal cell-derived factor-1 levels in normal healthy donors for allogeneic peripheral blood stem cell transplantation (PBSCT) and in patients for autologous PBSCT using an enzyme-linked immunosorbent assay. The average level of plasma stromal cell-derived factor-1 was 2197pg/ml before granulocyte colony-stimulating factor administration and 1899 pg/ml on day 4, demonstrating a significant decrease in the peripheral blood of healthy donors (P = 0.0003). In patients for autologous PBSCT, a significant decrease of plasma stromal cell-derived factor-1 in the peripheral blood was also observed (P = 0.0464). However, the physiologic gradient of stromal cell-derived factor-1 between peripheral blood and bone marrow was never inverted in normal healthy donors or in autologous PBSCT patients. Our results suggest that stromal cell-derived factor-1 may not be involved in the granulocyte colony-stimulating factor-induced release of CD34+ cells to the peripheral blood. Further studies of a possible additive effect of granulocyte colony-stimulating factor and stromal cell-derived factor-1 are warranted.

Original languageEnglish
Pages (from-to)651-654
Number of pages4
JournalBone Marrow Transplantation
Volume31
Issue number8
DOIs
Publication statusPublished - Apr 2003

Keywords

  • Granulocyte colony-stimulating factor
  • Peripheral blood stem cell mobilization
  • Stromal cell-derived factor-1

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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