Plasma orexin concentrations in patients on hemodialysis

Taro Sugimoto, Yoshio Nagake, Shigeru Sugimoto, Shigeru Akagi, Haruo Ichikawa, Yoshio Nakamura, Norio Ogawa, Hirofumi Makino

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Orexins A and B are neuropeptides that regulate feeding behavior and are localized exclusively in neurons within and around the lateral hypothalamic area. Intracerebroventricular injection of orexin A stimulates food consumption in rats. Plasma concentrations of orexins may reflect nutritional states and may have clinical significance in patients on hemodialysis. In this study, we investigated the relationship between plasma orexin concentrations and nutritional states in patients on hemodialysis. Method: We measured plasma orexin concentrations in patients on hemodialysis (HD group, n =67), patients with IgA nephropathy (n =10), patients with diabetes mellitus (n =11) and healthy controls (n =10). We examined the relationships between plasma orexin concentrations and nutritional indices. Results: Plasma orexin A concentrations were significantly higher in the HD group than in the control group and showed a significant correlation with serum creatinine. In all subjects, there was a positive correlation between the plasma orexin A concentration and the serum creatinine concentration, but there were no correlations between these concentrations in each group. In the HD group, plasma orexin A concentrations had a significant positive correlation with the serum albumin concentration and percent creatinine generation rate (%CGR). Multiple regression analysis demonstrated that %CGR was the only independent factor associated with plasma orexin A concentrations. Conclusion: Plasma orexin A concentrations are increased in patients on hemodialysis. It is possible that the kidney plays a major role in the clearance of orexins. The plasma orexin A concentration is significantly correlated with %CGR, and it may be able to be used as a clinical marker of the nutritional state in patients on hemodialysis.

Original languageEnglish
Pages (from-to)379-383
Number of pages5
JournalNephron
Volume90
Issue number4
DOIs
Publication statusPublished - Apr 25 2002

Fingerprint

Renal Dialysis
Creatinine
Orexins
Lateral Hypothalamic Area
Nutrition Assessment
Feeding Behavior
Serum
Serum Albumin
Immunoglobulin A
Diabetes Mellitus
Biomarkers
Regression Analysis
Kidney
Neurons
Food
Control Groups
Injections

Keywords

  • Creatinine generation rate
  • Hemodialysis
  • Nutritional state
  • Orexin

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Urology
  • Physiology (medical)

Cite this

Sugimoto, T., Nagake, Y., Sugimoto, S., Akagi, S., Ichikawa, H., Nakamura, Y., ... Makino, H. (2002). Plasma orexin concentrations in patients on hemodialysis. Nephron, 90(4), 379-383. https://doi.org/10.1159/000054724

Plasma orexin concentrations in patients on hemodialysis. / Sugimoto, Taro; Nagake, Yoshio; Sugimoto, Shigeru; Akagi, Shigeru; Ichikawa, Haruo; Nakamura, Yoshio; Ogawa, Norio; Makino, Hirofumi.

In: Nephron, Vol. 90, No. 4, 25.04.2002, p. 379-383.

Research output: Contribution to journalArticle

Sugimoto, T, Nagake, Y, Sugimoto, S, Akagi, S, Ichikawa, H, Nakamura, Y, Ogawa, N & Makino, H 2002, 'Plasma orexin concentrations in patients on hemodialysis', Nephron, vol. 90, no. 4, pp. 379-383. https://doi.org/10.1159/000054724
Sugimoto T, Nagake Y, Sugimoto S, Akagi S, Ichikawa H, Nakamura Y et al. Plasma orexin concentrations in patients on hemodialysis. Nephron. 2002 Apr 25;90(4):379-383. https://doi.org/10.1159/000054724
Sugimoto, Taro ; Nagake, Yoshio ; Sugimoto, Shigeru ; Akagi, Shigeru ; Ichikawa, Haruo ; Nakamura, Yoshio ; Ogawa, Norio ; Makino, Hirofumi. / Plasma orexin concentrations in patients on hemodialysis. In: Nephron. 2002 ; Vol. 90, No. 4. pp. 379-383.
@article{f1e45b32177740f6b4670416de5e4f8f,
title = "Plasma orexin concentrations in patients on hemodialysis",
abstract = "Background: Orexins A and B are neuropeptides that regulate feeding behavior and are localized exclusively in neurons within and around the lateral hypothalamic area. Intracerebroventricular injection of orexin A stimulates food consumption in rats. Plasma concentrations of orexins may reflect nutritional states and may have clinical significance in patients on hemodialysis. In this study, we investigated the relationship between plasma orexin concentrations and nutritional states in patients on hemodialysis. Method: We measured plasma orexin concentrations in patients on hemodialysis (HD group, n =67), patients with IgA nephropathy (n =10), patients with diabetes mellitus (n =11) and healthy controls (n =10). We examined the relationships between plasma orexin concentrations and nutritional indices. Results: Plasma orexin A concentrations were significantly higher in the HD group than in the control group and showed a significant correlation with serum creatinine. In all subjects, there was a positive correlation between the plasma orexin A concentration and the serum creatinine concentration, but there were no correlations between these concentrations in each group. In the HD group, plasma orexin A concentrations had a significant positive correlation with the serum albumin concentration and percent creatinine generation rate ({\%}CGR). Multiple regression analysis demonstrated that {\%}CGR was the only independent factor associated with plasma orexin A concentrations. Conclusion: Plasma orexin A concentrations are increased in patients on hemodialysis. It is possible that the kidney plays a major role in the clearance of orexins. The plasma orexin A concentration is significantly correlated with {\%}CGR, and it may be able to be used as a clinical marker of the nutritional state in patients on hemodialysis.",
keywords = "Creatinine generation rate, Hemodialysis, Nutritional state, Orexin",
author = "Taro Sugimoto and Yoshio Nagake and Shigeru Sugimoto and Shigeru Akagi and Haruo Ichikawa and Yoshio Nakamura and Norio Ogawa and Hirofumi Makino",
year = "2002",
month = "4",
day = "25",
doi = "10.1159/000054724",
language = "English",
volume = "90",
pages = "379--383",
journal = "Experimental Nephrology",
issn = "0028-2766",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - Plasma orexin concentrations in patients on hemodialysis

AU - Sugimoto, Taro

AU - Nagake, Yoshio

AU - Sugimoto, Shigeru

AU - Akagi, Shigeru

AU - Ichikawa, Haruo

AU - Nakamura, Yoshio

AU - Ogawa, Norio

AU - Makino, Hirofumi

PY - 2002/4/25

Y1 - 2002/4/25

N2 - Background: Orexins A and B are neuropeptides that regulate feeding behavior and are localized exclusively in neurons within and around the lateral hypothalamic area. Intracerebroventricular injection of orexin A stimulates food consumption in rats. Plasma concentrations of orexins may reflect nutritional states and may have clinical significance in patients on hemodialysis. In this study, we investigated the relationship between plasma orexin concentrations and nutritional states in patients on hemodialysis. Method: We measured plasma orexin concentrations in patients on hemodialysis (HD group, n =67), patients with IgA nephropathy (n =10), patients with diabetes mellitus (n =11) and healthy controls (n =10). We examined the relationships between plasma orexin concentrations and nutritional indices. Results: Plasma orexin A concentrations were significantly higher in the HD group than in the control group and showed a significant correlation with serum creatinine. In all subjects, there was a positive correlation between the plasma orexin A concentration and the serum creatinine concentration, but there were no correlations between these concentrations in each group. In the HD group, plasma orexin A concentrations had a significant positive correlation with the serum albumin concentration and percent creatinine generation rate (%CGR). Multiple regression analysis demonstrated that %CGR was the only independent factor associated with plasma orexin A concentrations. Conclusion: Plasma orexin A concentrations are increased in patients on hemodialysis. It is possible that the kidney plays a major role in the clearance of orexins. The plasma orexin A concentration is significantly correlated with %CGR, and it may be able to be used as a clinical marker of the nutritional state in patients on hemodialysis.

AB - Background: Orexins A and B are neuropeptides that regulate feeding behavior and are localized exclusively in neurons within and around the lateral hypothalamic area. Intracerebroventricular injection of orexin A stimulates food consumption in rats. Plasma concentrations of orexins may reflect nutritional states and may have clinical significance in patients on hemodialysis. In this study, we investigated the relationship between plasma orexin concentrations and nutritional states in patients on hemodialysis. Method: We measured plasma orexin concentrations in patients on hemodialysis (HD group, n =67), patients with IgA nephropathy (n =10), patients with diabetes mellitus (n =11) and healthy controls (n =10). We examined the relationships between plasma orexin concentrations and nutritional indices. Results: Plasma orexin A concentrations were significantly higher in the HD group than in the control group and showed a significant correlation with serum creatinine. In all subjects, there was a positive correlation between the plasma orexin A concentration and the serum creatinine concentration, but there were no correlations between these concentrations in each group. In the HD group, plasma orexin A concentrations had a significant positive correlation with the serum albumin concentration and percent creatinine generation rate (%CGR). Multiple regression analysis demonstrated that %CGR was the only independent factor associated with plasma orexin A concentrations. Conclusion: Plasma orexin A concentrations are increased in patients on hemodialysis. It is possible that the kidney plays a major role in the clearance of orexins. The plasma orexin A concentration is significantly correlated with %CGR, and it may be able to be used as a clinical marker of the nutritional state in patients on hemodialysis.

KW - Creatinine generation rate

KW - Hemodialysis

KW - Nutritional state

KW - Orexin

UR - http://www.scopus.com/inward/record.url?scp=0036222507&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036222507&partnerID=8YFLogxK

U2 - 10.1159/000054724

DO - 10.1159/000054724

M3 - Article

C2 - 11961395

AN - SCOPUS:0036222507

VL - 90

SP - 379

EP - 383

JO - Experimental Nephrology

JF - Experimental Nephrology

SN - 0028-2766

IS - 4

ER -