Plasma concentrations of natriuretic peptides in patients on hemodialysis

Maki Takahashi, Yoshio Nagake, Haruo Ichikawa, Kenji Kawabata, Hiroshi Nakazono, Kyoji Hirata, Toshio Ogura, Hirofumi Makino

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The usefulness of plasma atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-type natriuretic peptide (CNP), and cyclic guanosine 3',5'-monophosphate (cGMP) as markers of fluid overload was examined in hemodialysis (HD) patients without diabetes mellitus. Plasma concentrations of ANP, BNP, CNP, and cGMP all decreased significantly during HD. Before HD, there was a strong correlation between plasma concentrations of ANP and those of BNP, and plasma concentrations of cGMP correlated significantly with those of all three natriuretic peptides. The cardiothoracic ratio also correlated significantly with plasma concentrations of ANP and those of BNP before HD. Systolic blood pressure correlated significantly only with plasma concentrations of CNP, both before and after HD. Changes in body weight during HD correlated only with those in plasma ANP; there was thus no correlation between changes in body weight and those in plasma CNP. In conclusion, only plasma ANP is a useful marker of the proper volume and dry weight of HD patients. Furthermore, CNP may participate in cardiovascular regulation in HD patients in a manner different from those of ANP and BNP.

Original languageEnglish
Pages (from-to)19-30
Number of pages12
JournalResearch Communications in Molecular Pathology and Pharmacology
Volume92
Issue number1
Publication statusPublished - Apr 1996

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Natriuretic Peptides
Renal Dialysis
Atrial Natriuretic Factor
C-Type Natriuretic Peptide
Brain Natriuretic Peptide
Cyclic GMP
Body Weight Changes
Blood Pressure
Diabetes Mellitus
Weights and Measures

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pathology and Forensic Medicine

Cite this

Takahashi, M., Nagake, Y., Ichikawa, H., Kawabata, K., Nakazono, H., Hirata, K., ... Makino, H. (1996). Plasma concentrations of natriuretic peptides in patients on hemodialysis. Research Communications in Molecular Pathology and Pharmacology, 92(1), 19-30.

Plasma concentrations of natriuretic peptides in patients on hemodialysis. / Takahashi, Maki; Nagake, Yoshio; Ichikawa, Haruo; Kawabata, Kenji; Nakazono, Hiroshi; Hirata, Kyoji; Ogura, Toshio; Makino, Hirofumi.

In: Research Communications in Molecular Pathology and Pharmacology, Vol. 92, No. 1, 04.1996, p. 19-30.

Research output: Contribution to journalArticle

Takahashi, M, Nagake, Y, Ichikawa, H, Kawabata, K, Nakazono, H, Hirata, K, Ogura, T & Makino, H 1996, 'Plasma concentrations of natriuretic peptides in patients on hemodialysis', Research Communications in Molecular Pathology and Pharmacology, vol. 92, no. 1, pp. 19-30.
Takahashi M, Nagake Y, Ichikawa H, Kawabata K, Nakazono H, Hirata K et al. Plasma concentrations of natriuretic peptides in patients on hemodialysis. Research Communications in Molecular Pathology and Pharmacology. 1996 Apr;92(1):19-30.
Takahashi, Maki ; Nagake, Yoshio ; Ichikawa, Haruo ; Kawabata, Kenji ; Nakazono, Hiroshi ; Hirata, Kyoji ; Ogura, Toshio ; Makino, Hirofumi. / Plasma concentrations of natriuretic peptides in patients on hemodialysis. In: Research Communications in Molecular Pathology and Pharmacology. 1996 ; Vol. 92, No. 1. pp. 19-30.
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