Plasma Blood Coagulation Without Involving the Activation of Platelets and Coagulation Factors

Sanae Ikehara, Hajime Sakakita, Kenji Ishikawa, Yoshihiro Akimoto, Takashi Yamaguchi, Masahiro Yamagishi, Jaeho Kim, Masashi Ueda, Jun Ichiro Ikeda, Hayao Nakanishi, Nobuyuki Shimizu, Masaru Hori, Yuzuru Ikehara

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The objective of this study is to determine whether there is a pathway different from the natural blood coagulation process involved in the plasma-induced activation of platelets and coagulation factors. Plasma treatment of bleeding wounds generated glomerular structures, which could be detected in high-magnification scanning electron microscopy images, and plasma flares produced aggregation on the surface of solutions containing bovine serum albumin, ovalbumin (OVA), or similar protein material. Ultramicroscopic analysis of the plasma-generated aggregation of OVA indicated a possible mechanism to explain the particle formation and fusion as a monotonous solid appearance. This study suggests that plasma coagulation involves aggregations of materials in blood in addition to the activation of platelets and coagulation factors by plasma treatment.

Original languageEnglish
Pages (from-to)1348-1353
Number of pages6
JournalPlasma Processes and Polymers
Volume12
Issue number12
DOIs
Publication statusPublished - Dec 1 2015

Keywords

  • coagulation
  • hemostasis
  • nonthermal plasma
  • protein aggregation

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Polymers and Plastics

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  • Cite this

    Ikehara, S., Sakakita, H., Ishikawa, K., Akimoto, Y., Yamaguchi, T., Yamagishi, M., Kim, J., Ueda, M., Ikeda, J. I., Nakanishi, H., Shimizu, N., Hori, M., & Ikehara, Y. (2015). Plasma Blood Coagulation Without Involving the Activation of Platelets and Coagulation Factors. Plasma Processes and Polymers, 12(12), 1348-1353. https://doi.org/10.1002/ppap.201500132