Plasma Blood Coagulation Without Involving the Activation of Platelets and Coagulation Factors

Sanae Ikehara, Hajime Sakakita, Kenji Ishikawa, Yoshihiro Akimoto, Takashi Yamaguchi, Masahiro Yamagishi, Jaeho Kim, Masashi Ueda, Jun Ichiro Ikeda, Hayao Nakanishi, Nobuyuki Shimizu, Masaru Hori, Yuzuru Ikehara

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The objective of this study is to determine whether there is a pathway different from the natural blood coagulation process involved in the plasma-induced activation of platelets and coagulation factors. Plasma treatment of bleeding wounds generated glomerular structures, which could be detected in high-magnification scanning electron microscopy images, and plasma flares produced aggregation on the surface of solutions containing bovine serum albumin, ovalbumin (OVA), or similar protein material. Ultramicroscopic analysis of the plasma-generated aggregation of OVA indicated a possible mechanism to explain the particle formation and fusion as a monotonous solid appearance. This study suggests that plasma coagulation involves aggregations of materials in blood in addition to the activation of platelets and coagulation factors by plasma treatment.

Original languageEnglish
Pages (from-to)1348-1353
Number of pages6
JournalPlasma Processes and Polymers
Volume12
Issue number12
DOIs
Publication statusPublished - Dec 1 2015

Fingerprint

blood coagulation
Blood Coagulation Factors
coagulation
Platelets
Coagulation
platelets
Blood
Chemical activation
activation
Plasmas
Agglomeration
Ovalbumin
bleeding
Bovine Serum Albumin
magnification
albumins
serums
flares
blood
Fusion reactions

Keywords

  • coagulation
  • hemostasis
  • nonthermal plasma
  • protein aggregation

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Polymers and Plastics

Cite this

Ikehara, S., Sakakita, H., Ishikawa, K., Akimoto, Y., Yamaguchi, T., Yamagishi, M., ... Ikehara, Y. (2015). Plasma Blood Coagulation Without Involving the Activation of Platelets and Coagulation Factors. Plasma Processes and Polymers, 12(12), 1348-1353. https://doi.org/10.1002/ppap.201500132

Plasma Blood Coagulation Without Involving the Activation of Platelets and Coagulation Factors. / Ikehara, Sanae; Sakakita, Hajime; Ishikawa, Kenji; Akimoto, Yoshihiro; Yamaguchi, Takashi; Yamagishi, Masahiro; Kim, Jaeho; Ueda, Masashi; Ikeda, Jun Ichiro; Nakanishi, Hayao; Shimizu, Nobuyuki; Hori, Masaru; Ikehara, Yuzuru.

In: Plasma Processes and Polymers, Vol. 12, No. 12, 01.12.2015, p. 1348-1353.

Research output: Contribution to journalArticle

Ikehara, S, Sakakita, H, Ishikawa, K, Akimoto, Y, Yamaguchi, T, Yamagishi, M, Kim, J, Ueda, M, Ikeda, JI, Nakanishi, H, Shimizu, N, Hori, M & Ikehara, Y 2015, 'Plasma Blood Coagulation Without Involving the Activation of Platelets and Coagulation Factors', Plasma Processes and Polymers, vol. 12, no. 12, pp. 1348-1353. https://doi.org/10.1002/ppap.201500132
Ikehara S, Sakakita H, Ishikawa K, Akimoto Y, Yamaguchi T, Yamagishi M et al. Plasma Blood Coagulation Without Involving the Activation of Platelets and Coagulation Factors. Plasma Processes and Polymers. 2015 Dec 1;12(12):1348-1353. https://doi.org/10.1002/ppap.201500132
Ikehara, Sanae ; Sakakita, Hajime ; Ishikawa, Kenji ; Akimoto, Yoshihiro ; Yamaguchi, Takashi ; Yamagishi, Masahiro ; Kim, Jaeho ; Ueda, Masashi ; Ikeda, Jun Ichiro ; Nakanishi, Hayao ; Shimizu, Nobuyuki ; Hori, Masaru ; Ikehara, Yuzuru. / Plasma Blood Coagulation Without Involving the Activation of Platelets and Coagulation Factors. In: Plasma Processes and Polymers. 2015 ; Vol. 12, No. 12. pp. 1348-1353.
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