Plasma adrenomedullin levels in patients on hemodialysis

Hiroko Yamasaki, Yoshio Nagake, Shigeru Akagi, Taro Sugimoto, Haruo Ichikawa, Hirofumi Makino

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Adrenomedullin (AM) is a hypotensive peptide that has recently been isolated from human pheochromocytoma. In this study, we measured plasma AM concentrations in 54 patients on hemodialysis (HD) and examined the clinical significance. We also evaluated the effects of high-flux and low-flux dialysis membranes on plasma AM levels. The average value of plasma AM at pre-HD (4.44 ± 0.16 fmol/ml) was significantly elevated compared with that in 44 healthy volunteers (1.31 ± 1.41 fmol/ml) (p lt; 0.0001). The plasma AM concentrations at pre-HD showed a negative correlation with age and mean blood pressure (MBP) at pre-HD. The plasma AM concentrations at post-HD showed a negative correlation with MBP at post-HD and a negative correlation with the reduction rate of AM. Multiple regression analysis showed that age and MBP were independent factors associated with plasma AM at pre-HD and that MBP and reduction rate of AM were independent factors associated with plasma AM at post-HD. We investigated the differences between high-flux dialyzers (PS-UW, PS-N and FB-F) and a low-flux dialyzer (AM-BC-F), and we found that high-flux dialyzers removed plasma AM more efficiently than a low-flux dialyzer did. In addition, in 3 patients on HD, plasma AM levels decreased significantly during isovolumic dialysis using a high-flux dialyzer, despite the fact that there were no significant changes in MBP and ANP. In conclusion, elevation in plasma AM level causes a fall in MBP in patients on HD, therefore, removal of AM by HD treatment using a high-flux dialyzer contributes to the stability of blood pressure during HD.

Original languageEnglish
Pages (from-to)20-25
Number of pages6
JournalNephron
Volume89
Issue number1
DOIs
Publication statusPublished - Sep 11 2001

Fingerprint

Adrenomedullin
Renal Dialysis
Blood Pressure
Dialysis
Atrial Natriuretic Factor
Pheochromocytoma

Keywords

  • Adrenomedullin
  • Atrial natriuretic peptide
  • Hemodialysis

ASJC Scopus subject areas

  • Nephrology

Cite this

Yamasaki, H., Nagake, Y., Akagi, S., Sugimoto, T., Ichikawa, H., & Makino, H. (2001). Plasma adrenomedullin levels in patients on hemodialysis. Nephron, 89(1), 20-25. https://doi.org/10.1159/000046038

Plasma adrenomedullin levels in patients on hemodialysis. / Yamasaki, Hiroko; Nagake, Yoshio; Akagi, Shigeru; Sugimoto, Taro; Ichikawa, Haruo; Makino, Hirofumi.

In: Nephron, Vol. 89, No. 1, 11.09.2001, p. 20-25.

Research output: Contribution to journalArticle

Yamasaki, H, Nagake, Y, Akagi, S, Sugimoto, T, Ichikawa, H & Makino, H 2001, 'Plasma adrenomedullin levels in patients on hemodialysis', Nephron, vol. 89, no. 1, pp. 20-25. https://doi.org/10.1159/000046038
Yamasaki H, Nagake Y, Akagi S, Sugimoto T, Ichikawa H, Makino H. Plasma adrenomedullin levels in patients on hemodialysis. Nephron. 2001 Sep 11;89(1):20-25. https://doi.org/10.1159/000046038
Yamasaki, Hiroko ; Nagake, Yoshio ; Akagi, Shigeru ; Sugimoto, Taro ; Ichikawa, Haruo ; Makino, Hirofumi. / Plasma adrenomedullin levels in patients on hemodialysis. In: Nephron. 2001 ; Vol. 89, No. 1. pp. 20-25.
@article{c40b5abc4c574eac80af7da7f4130e3b,
title = "Plasma adrenomedullin levels in patients on hemodialysis",
abstract = "Adrenomedullin (AM) is a hypotensive peptide that has recently been isolated from human pheochromocytoma. In this study, we measured plasma AM concentrations in 54 patients on hemodialysis (HD) and examined the clinical significance. We also evaluated the effects of high-flux and low-flux dialysis membranes on plasma AM levels. The average value of plasma AM at pre-HD (4.44 ± 0.16 fmol/ml) was significantly elevated compared with that in 44 healthy volunteers (1.31 ± 1.41 fmol/ml) (p lt; 0.0001). The plasma AM concentrations at pre-HD showed a negative correlation with age and mean blood pressure (MBP) at pre-HD. The plasma AM concentrations at post-HD showed a negative correlation with MBP at post-HD and a negative correlation with the reduction rate of AM. Multiple regression analysis showed that age and MBP were independent factors associated with plasma AM at pre-HD and that MBP and reduction rate of AM were independent factors associated with plasma AM at post-HD. We investigated the differences between high-flux dialyzers (PS-UW, PS-N and FB-F) and a low-flux dialyzer (AM-BC-F), and we found that high-flux dialyzers removed plasma AM more efficiently than a low-flux dialyzer did. In addition, in 3 patients on HD, plasma AM levels decreased significantly during isovolumic dialysis using a high-flux dialyzer, despite the fact that there were no significant changes in MBP and ANP. In conclusion, elevation in plasma AM level causes a fall in MBP in patients on HD, therefore, removal of AM by HD treatment using a high-flux dialyzer contributes to the stability of blood pressure during HD.",
keywords = "Adrenomedullin, Atrial natriuretic peptide, Hemodialysis",
author = "Hiroko Yamasaki and Yoshio Nagake and Shigeru Akagi and Taro Sugimoto and Haruo Ichikawa and Hirofumi Makino",
year = "2001",
month = "9",
day = "11",
doi = "10.1159/000046038",
language = "English",
volume = "89",
pages = "20--25",
journal = "Experimental Nephrology",
issn = "0028-2766",
publisher = "S. Karger AG",
number = "1",

}

TY - JOUR

T1 - Plasma adrenomedullin levels in patients on hemodialysis

AU - Yamasaki, Hiroko

AU - Nagake, Yoshio

AU - Akagi, Shigeru

AU - Sugimoto, Taro

AU - Ichikawa, Haruo

AU - Makino, Hirofumi

PY - 2001/9/11

Y1 - 2001/9/11

N2 - Adrenomedullin (AM) is a hypotensive peptide that has recently been isolated from human pheochromocytoma. In this study, we measured plasma AM concentrations in 54 patients on hemodialysis (HD) and examined the clinical significance. We also evaluated the effects of high-flux and low-flux dialysis membranes on plasma AM levels. The average value of plasma AM at pre-HD (4.44 ± 0.16 fmol/ml) was significantly elevated compared with that in 44 healthy volunteers (1.31 ± 1.41 fmol/ml) (p lt; 0.0001). The plasma AM concentrations at pre-HD showed a negative correlation with age and mean blood pressure (MBP) at pre-HD. The plasma AM concentrations at post-HD showed a negative correlation with MBP at post-HD and a negative correlation with the reduction rate of AM. Multiple regression analysis showed that age and MBP were independent factors associated with plasma AM at pre-HD and that MBP and reduction rate of AM were independent factors associated with plasma AM at post-HD. We investigated the differences between high-flux dialyzers (PS-UW, PS-N and FB-F) and a low-flux dialyzer (AM-BC-F), and we found that high-flux dialyzers removed plasma AM more efficiently than a low-flux dialyzer did. In addition, in 3 patients on HD, plasma AM levels decreased significantly during isovolumic dialysis using a high-flux dialyzer, despite the fact that there were no significant changes in MBP and ANP. In conclusion, elevation in plasma AM level causes a fall in MBP in patients on HD, therefore, removal of AM by HD treatment using a high-flux dialyzer contributes to the stability of blood pressure during HD.

AB - Adrenomedullin (AM) is a hypotensive peptide that has recently been isolated from human pheochromocytoma. In this study, we measured plasma AM concentrations in 54 patients on hemodialysis (HD) and examined the clinical significance. We also evaluated the effects of high-flux and low-flux dialysis membranes on plasma AM levels. The average value of plasma AM at pre-HD (4.44 ± 0.16 fmol/ml) was significantly elevated compared with that in 44 healthy volunteers (1.31 ± 1.41 fmol/ml) (p lt; 0.0001). The plasma AM concentrations at pre-HD showed a negative correlation with age and mean blood pressure (MBP) at pre-HD. The plasma AM concentrations at post-HD showed a negative correlation with MBP at post-HD and a negative correlation with the reduction rate of AM. Multiple regression analysis showed that age and MBP were independent factors associated with plasma AM at pre-HD and that MBP and reduction rate of AM were independent factors associated with plasma AM at post-HD. We investigated the differences between high-flux dialyzers (PS-UW, PS-N and FB-F) and a low-flux dialyzer (AM-BC-F), and we found that high-flux dialyzers removed plasma AM more efficiently than a low-flux dialyzer did. In addition, in 3 patients on HD, plasma AM levels decreased significantly during isovolumic dialysis using a high-flux dialyzer, despite the fact that there were no significant changes in MBP and ANP. In conclusion, elevation in plasma AM level causes a fall in MBP in patients on HD, therefore, removal of AM by HD treatment using a high-flux dialyzer contributes to the stability of blood pressure during HD.

KW - Adrenomedullin

KW - Atrial natriuretic peptide

KW - Hemodialysis

UR - http://www.scopus.com/inward/record.url?scp=0034871208&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034871208&partnerID=8YFLogxK

U2 - 10.1159/000046038

DO - 10.1159/000046038

M3 - Article

C2 - 11528227

AN - SCOPUS:0034871208

VL - 89

SP - 20

EP - 25

JO - Experimental Nephrology

JF - Experimental Nephrology

SN - 0028-2766

IS - 1

ER -