Plasma adiponectin levels predict cardiovascular events in the observational Arita Cohort Study in Japan: The importance of the plasma adiponectin levels

Chun Yen Chen, Masanori Asakura, Hiroshi Asanuma, Takuya Hasegawa, Jun Tanaka, Norihisa Toh, Kyung Duk Min, Hideaki Kanzaki, Hiroyuki Takahama, Makoto Amaki, Yumi Itoh, Go Ichien, Yoko Okumoto, Toru Funahashi, Jiyoong Kim, Masafumi Kitakaze

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

As the plasma level of adiponectin is related to metabolic syndrome and cardiovascular events, a low plasma adiponectin level may either cause or trigger cardiovascular disorders. The purpose of this study was to determine whether a low adiponectin level contributes to cardiovascular events, and to investigate the factors influencing adiponectin in the Japanese Arita-cho cohort study.We followed about 2000 subjects in Arita-cho, Saga, Japan as a cohort study, and we enrolled 637 subjects (205 men; 65.18.3 years old) who participated in annual health checks from 2005 to 2008 and underwent measurement of the plasma adiponectin level and an oral glucose tolerance test. We monitored the incidence of cardiovascular or cerebrovascular events in these subjects until the end of 2010, discontinuing follow-up at 3 years after the start of enrollment. Subjects with low plasma adiponectin levels (≥10.5 ng ml-1) had a higher incidence of newly diagnosed cardiovascular diseases such as acute heart failure or acute myocardial infarction than those with high plasma adiponectin levels (≥10.5 ng ml-1) over an average of 2.95 years of follow-up. Multivariate analysis showed that the adiponectin level was predicted by the following parameters in all subjects: age (Β=-0.16), male gender (Β=-0.267), homeostasis model assessment of insulin resistance (Β=-0.140) and the plasma levels of high-density lipoprotein cholesterol (Β=-0.104), uric acid (Β=-0.13), triglycerides (Β=-0.169) and brain natriuretic peptide (Β=-0.151). The difference in plasma glucose before and 120 min after the intake of a 75-g glucose load did not influence the plasma adiponectin level. The plasma adiponectin level is useful for predicting cardiovascular events, and is a measure of the risk of lifestyle-related diseases.

Original languageEnglish
Pages (from-to)843-848
Number of pages6
JournalHypertension Research
Volume35
Issue number8
DOIs
Publication statusPublished - Aug 1 2012
Externally publishedYes

Keywords

  • adiponectin
  • myocardial infarction
  • stroke

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Chen, C. Y., Asakura, M., Asanuma, H., Hasegawa, T., Tanaka, J., Toh, N., Min, K. D., Kanzaki, H., Takahama, H., Amaki, M., Itoh, Y., Ichien, G., Okumoto, Y., Funahashi, T., Kim, J., & Kitakaze, M. (2012). Plasma adiponectin levels predict cardiovascular events in the observational Arita Cohort Study in Japan: The importance of the plasma adiponectin levels. Hypertension Research, 35(8), 843-848. https://doi.org/10.1038/hr.2012.42