Plant autophagy is responsible for peroxisomal transition and plays an important role in the maintenance of peroxisomal quality

Michitaro Shibata, Kazusato Oikawa, Kohki Yoshimoto, Shino Goto-Yamada, Shoji Mano, Kenji Yamada, Maki Kondo, Makoto Hayashi, Wataru Sakamoto, Yoshinori Ohsumi, Mikio Nishimura

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In photosynthetic cells, a large amount of hydrogen peroxide is produced in peroxisomes through photorespiration, which is a metabolic pathway related to photosynthesis. Hydrogen peroxide, a reactive oxygen species, oxidizes peroxisomal proteins and membrane lipids, resulting in a decrease in peroxisomal quality. We demonstrate that the autophagic system is responsible for the elimination of oxidized peroxisomes in plant. We isolated Arabidopsis mutants that accumulated oxidized peroxisomes, which formed large aggregates. We revealed that these mutants were defective in autophagy-related (ATG) genes and that the aggregated peroxisomes were selectively targeted by the autophagic machinery. These findings suggest that autophagy plays an important role in the quality control of peroxisomes by the selective degradation of oxidized peroxisomes. In addition, the results suggest that autophagy is also responsible for the functional transition of glyoxysomes to leaf peroxisomes.

Original languageEnglish
Pages (from-to)936-937
Number of pages2
JournalAutophagy
Volume10
Issue number5
DOIs
Publication statusPublished - 2014

Fingerprint

Peroxisomes
Autophagy
Hydrogen Peroxide
Glyoxysomes
Photosynthesis
Membrane Lipids
Metabolic Networks and Pathways
Arabidopsis
Quality Control
Reactive Oxygen Species
Genes

Keywords

  • Arabidopsis thaliana
  • Glyoxysome leaf peroxisome
  • Hydrogen peroxide
  • Peroxisome
  • Peroxisome transition
  • Pexophagy

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Cite this

Shibata, M., Oikawa, K., Yoshimoto, K., Goto-Yamada, S., Mano, S., Yamada, K., ... Nishimura, M. (2014). Plant autophagy is responsible for peroxisomal transition and plays an important role in the maintenance of peroxisomal quality. Autophagy, 10(5), 936-937. https://doi.org/10.4161/auto.28529

Plant autophagy is responsible for peroxisomal transition and plays an important role in the maintenance of peroxisomal quality. / Shibata, Michitaro; Oikawa, Kazusato; Yoshimoto, Kohki; Goto-Yamada, Shino; Mano, Shoji; Yamada, Kenji; Kondo, Maki; Hayashi, Makoto; Sakamoto, Wataru; Ohsumi, Yoshinori; Nishimura, Mikio.

In: Autophagy, Vol. 10, No. 5, 2014, p. 936-937.

Research output: Contribution to journalArticle

Shibata, M, Oikawa, K, Yoshimoto, K, Goto-Yamada, S, Mano, S, Yamada, K, Kondo, M, Hayashi, M, Sakamoto, W, Ohsumi, Y & Nishimura, M 2014, 'Plant autophagy is responsible for peroxisomal transition and plays an important role in the maintenance of peroxisomal quality', Autophagy, vol. 10, no. 5, pp. 936-937. https://doi.org/10.4161/auto.28529
Shibata, Michitaro ; Oikawa, Kazusato ; Yoshimoto, Kohki ; Goto-Yamada, Shino ; Mano, Shoji ; Yamada, Kenji ; Kondo, Maki ; Hayashi, Makoto ; Sakamoto, Wataru ; Ohsumi, Yoshinori ; Nishimura, Mikio. / Plant autophagy is responsible for peroxisomal transition and plays an important role in the maintenance of peroxisomal quality. In: Autophagy. 2014 ; Vol. 10, No. 5. pp. 936-937.
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AU - Yamada, Kenji

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