Placenta growth factor is abundantly expressed in human cervical squamous cell carcinoma

J. Kodama, N. Seki, K. Tokumo, Y. Nakanishi, M. Yoshinouchi, T. Kudo

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


Tumor angiogenesis is essential for solid tumor growth. The object of this study was to investigate the presence of newly identified angiogenic factor, placenta growth factor (PlGF) in human cervical cancers. The expression of PlGF mRNA was assessed by RT-PCR in 29 patients with cervical cancer. Fifteen out of 29 cervical cancers expressed a certain level of PlGF mRNA. In addition, the expression levels of PlGF mRNA in squamous cell carcinomas were significantly higher than those in adenocarcinomas. There was no correlation between the expression of PlGF mRNA and FIGO stage. These results indicate that the expression of PlGF may be implicated in the promotion of angiogenesis in human cervical squamous cell carcinomas, but not in human cervical adenocarcinomas.

Original languageEnglish
Pages (from-to)508-510
Number of pages3
JournalEuropean Journal of Gynaecological Oncology
Issue number6
Publication statusPublished - Dec 17 1997


  • Angiogenesis
  • Cervical cancer
  • Placenta growth factor

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology


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