Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry

Hidefumi Yoshioka, Chikara Meno, Kazuko Koshiba, Minoru Sugihara, Hiroyuki Itoh, Yoshiyasu Ishimaru, Takashi Inoue, Hideyo Ohuchi, Elena V. Semina, Jeffrey C. Murray, Hiroshi Hamada, Sumihare Noji

Research output: Contribution to journalArticle

297 Citations (Scopus)

Abstract

Signaling molecules such as Activin, Sonic hedgehog, Nodal, Lefty, and Vg1 have been found to be involved in determination of left-right (L-R) asymmetry in the chick, mouse, or frog. However, a common signaling pathway has not yet been identified in vertebrates. We report that Pitx2, a bicoid- type homeobox gene expressed asymmetrically in the left lateral plate mesoderm, may be involved in determination of L-R asymmetry in both mouse and chick. Since Pitx2 appears to be downstream of lefty-1 in the mouse pathway, we examined whether mouse Lefty proteins could affect the expression of Pitx2 in the chick. Our results indicate that a common pathway from lefty-1 to Pitx2 likely exists for determination of L-R asymmetry in vertebrates.

Original languageEnglish
Pages (from-to)299-305
Number of pages7
JournalCell
Volume94
Issue number3
DOIs
Publication statusPublished - Aug 7 1998
Externally publishedYes

Fingerprint

Homeobox Genes
Left-Right Determination Factors
Genes
Activins
Vertebrates
Molecules
Hedgehogs
Mesoderm
Anura

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Yoshioka, H., Meno, C., Koshiba, K., Sugihara, M., Itoh, H., Ishimaru, Y., ... Noji, S. (1998). Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry. Cell, 94(3), 299-305. https://doi.org/10.1016/S0092-8674(00)81473-7

Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry. / Yoshioka, Hidefumi; Meno, Chikara; Koshiba, Kazuko; Sugihara, Minoru; Itoh, Hiroyuki; Ishimaru, Yoshiyasu; Inoue, Takashi; Ohuchi, Hideyo; Semina, Elena V.; Murray, Jeffrey C.; Hamada, Hiroshi; Noji, Sumihare.

In: Cell, Vol. 94, No. 3, 07.08.1998, p. 299-305.

Research output: Contribution to journalArticle

Yoshioka, H, Meno, C, Koshiba, K, Sugihara, M, Itoh, H, Ishimaru, Y, Inoue, T, Ohuchi, H, Semina, EV, Murray, JC, Hamada, H & Noji, S 1998, 'Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry', Cell, vol. 94, no. 3, pp. 299-305. https://doi.org/10.1016/S0092-8674(00)81473-7
Yoshioka, Hidefumi ; Meno, Chikara ; Koshiba, Kazuko ; Sugihara, Minoru ; Itoh, Hiroyuki ; Ishimaru, Yoshiyasu ; Inoue, Takashi ; Ohuchi, Hideyo ; Semina, Elena V. ; Murray, Jeffrey C. ; Hamada, Hiroshi ; Noji, Sumihare. / Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry. In: Cell. 1998 ; Vol. 94, No. 3. pp. 299-305.
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