Piperacillin and ceftazidime produce the strongest synergistic phage–antibiotic effect in Pseudomonas aeruginosa

Jumpei Uchiyama, Ryu Shigehisa, Tadahiro Nasukawa, Keijiro Mizukami, Iyo Takemura-Uchiyama, Takako Ujihara, Hironobu Murakami, Ichiro Imanishi, Koji Nishifuji, Masahiro Sakaguchi, Shigenobu Matsuzaki

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

The combined use of phage and antibiotics can show synergistic antimicrobial effects, so-called phage–antibiotic synergy (PAS). Here, we screened and examined PAS against Pseudomonas aeruginosa in vitro. Testing four different phages infecting P. aeruginosa, phage KPP22 classified within the family Myoviridae genus Pbunavirus showed PAS with the widest range of antibiotics, and showed PAS with anti-Pseudomonas drugs such as piperacillin and ceftazidime. Thus, evidence suggests that the combined use of phage and antibiotics is a promising therapeutic strategy against P. aeruginosa infections, with consideration needed regarding the optimal selection and adequate application timing of these phages and antibiotics.

Original languageEnglish
Pages (from-to)1941-1948
Number of pages8
JournalArchives of Virology
Volume163
Issue number7
DOIs
Publication statusPublished - Jul 1 2018
Externally publishedYes

ASJC Scopus subject areas

  • Virology

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