Pinpoint drug delivery system using hollow bio-nanoparticles

Tadanori Yamada, Masaharu Seno, Akihiko Kondo, Masakazu Ueda, Katsuyuki Tanizawa, Shun'ichi Kuroda

Research output: Contribution to journalArticlepeer-review


Hepatitis B virus envelope L proteins produced in yeast cells form hollow nanoparticles (L particles, average diameter 220 nm) displaying human liver-specific receptor. Recently, the L particles were found to incorporate genes, proteins, and drugs, and act as an efficient pinpoint delivery system to human liver-derived tissues in xenograft models. By substituting the epidermal growth factor (EGF) for human liver-specific receptor, the mutated L particles showed the affinity to the EGF receptor, not to human liver. Other similar HBV envelope proteins, e.g., M and S particles, have already been commercialized for hepatitis B vaccine, strongly suggesting the safety of L particles in human. These results indicate that the hollow bio-nanoparticles are a promising candidate for the next-generation platform of DDS, especially that related to gene therapy.

Original languageEnglish
Pages (from-to)606-612
Number of pages7
Issue number12
Publication statusPublished - Dec 2004


  • Drug delivery system
  • Gene therapy
  • Hemophilia
  • Hepatitis B virus
  • In vivo
  • Nanoparticle
  • Retargeting
  • Yeast

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Materials Science (miscellaneous)
  • Environmental Science(all)
  • Polymers and Plastics


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