PHYSIOMICS OF CORONARY PERFUSION AND CARDIAC PUMPING

Fumihiko Kajiya, Masahito Kajiya, Taro Morimoto, Tatsuo Iwasaki, Yousuke Inai, Masanori Hirota, Takahiko Kiyooka, Yuki Morizane, Takehiro Miyasaka, Satoshi Mohri, Juichiro Shimizu

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Physiome is considered to be a powerful successor to the genome. Physiome refers to a quantitative description of the physiologic dynamics or functions of the intact organism. It includes integration of knowledge through functional modules and modelling of hierarchic system elements of biologic systems. Biomechanics offers potent tools to promote the physiome concept. By using modern microvisualization technology with physiomic model of coronary circulatory network, this chapter introduces our physiomic approach to coronary microcirculation, which supplies oxygen and nutrients to heart muscles. The heart is unique, among other organs, in that coronary arterial flow is exclusively diastolic while venous flow is systolic. That is, blood pooled in coronary microvessels (during diastole) is squeezed out to the coronary vein by myocardial contraction. In this chapter, we first describe the biomechanical interaction between coronary blood flow and cardiac contraction. Then, the physiome of coronary capillary network and its functions are discussed.

Original languageEnglish
Title of host publicationCardiac Perfusion and Pumping Engineering
Subtitle of host publicationVolume 1
PublisherWorld Scientific Publishing Co.
Pages1-15
Number of pages15
Volume1
ISBN (Electronic)9789812775597
ISBN (Print)9812706968, 9789812706966
DOIs
Publication statusPublished - Jan 1 2007

ASJC Scopus subject areas

  • Medicine(all)

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