Physiome of coronary circulation: Simulation of autoregulated coronary flow

M. Kagiyama, Y. Ogasawara, O. Hiramatsu, H. Tachibana, F. Kajiya, H. Kagotani, T. Okamoto

Research output: Contribution to journalArticlepeer-review


The purpose of this study was to explain intramyocardial coronary microvascular diameter changes during a cardiac cycle observed with our needle-probe CCD videomicroscope by a model simulation. An autoregulated coronary flow model was constructed by including a control element that regulates blood flow by tuning myocardial elastance to our previous model. The relationship between mean flow and purfusion pressure by model experiments coincided well with the published data. The relative arteriolar diameters maximal in a cardiac cycle were calculated based on simulation. The changes of diameters were small, coinciding with the experimental observation.

Original languageEnglish
Pages (from-to)353-356
Number of pages4
JournalComputers in Cardiology
Publication statusPublished - Jan 1 2001

ASJC Scopus subject areas

  • Computer Science Applications
  • Cardiology and Cardiovascular Medicine


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