Physiological involvement of placental endothelin-1 and prostaglandin F in uteroplacental circulatory disturbance in pregnant rats exposed to heat stress

Hiroyuki Nakamura, Ichiyo Matsuzaki, Kotaro Hatta, Keiki Ogino

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Several studies suggest that heat stress affects placental functions including uteroplacental circulation, subsequently leading to pregnancy failure and birth weight reduction. To clarify the involvement of endothelin and placental prostaglandin (PG) systems in the uteroplacental circulation during heat stress, we examined the effects of i.v. administration of the endothelin receptor antagonist bosentan and the cyclooxygenase inhibitor indomethacin on uteroplacental blood flow and on placental PGE2 and PGF levels and their 13,14-dyhydro-15-keto-metabolites (PGEM and PGFM, respectively) in heat-exposed or non-heat-exposed pregnant rats. The administration of bosentan or indomethacin did not change uteroplacental blood flow in non-heat-exposed pregnant rats. In contrast, heat reduced uteroplacental blood flow in pregnant rats, but the reduction was reversed by the administration of bosentan or indomethacin before heat exposure. Heat did not change placental PGE2 or PGEM levels, but in pregnant rats it increased placental PGF, and PGFM levels, which were reversed by bosentan or indomethacin. Our results suggest that the activation of placental endothelin receptor and PGF systems are involved in the uteroplacental circulatory disturbances produced by heat. PGF systems activated by heat may be involved in the vasoconstricting effects of endothelin-A and -B receptors during heat exposure.

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalCanadian Journal of Physiology and Pharmacology
Volume82
Issue number4
DOIs
Publication statusPublished - Apr 2004

Keywords

  • Blood flow
  • Endothelin
  • Placenta
  • Pregnancy
  • Prostaglandin

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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