Physico-chemical Properties of Fatty Acids for Assessing the Threshold Concentration to Enhance the Absorption of a Hydrophilic Substance

Yukitaka Kimura, Yasuo Hosoda, Motohiro Shima, Shuji Adachi, Ryuichi Matsuno

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The effects of natural and non-natural fatty acids on enhancing the absorption of a hydrophilic marker through a human epithelial cell (Caco-2) monolayer were measured to elucidate the properties of the fatty acids. Fatty acids from C9 to C14 enhanced the absorption depending on the concentration and the carbon chain length. Those fatty acids with longer chains gave a higher permeability coefficient at low concentrations and a lower toxicity than those with shorter chains. The surface energy lowering coefficient (SELC), an intrinsic physico-chemical property, and the critical micellar concentration (CMC) were good criteria for identifying the threshold concentrations of a fatty acid to significantly enhance absorption.

Original languageEnglish
Pages (from-to)443-447
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume62
Issue number3
Publication statusPublished - Mar 1998
Externally publishedYes

Fingerprint

Chemical properties
physicochemical properties
Fatty Acids
fatty acids
Hydraulic conductivity
Chain length
Interfacial energy
Toxicity
Monolayers
Permeability
permeability
epithelial cells
Carbon
Epithelial Cells
toxicity
carbon
energy

Keywords

  • Absorption enhancement
  • Caco-2
  • Fatty acid
  • Physico-chemical property

ASJC Scopus subject areas

  • Food Science
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biotechnology
  • Chemistry (miscellaneous)
  • Applied Microbiology and Biotechnology

Cite this

Physico-chemical Properties of Fatty Acids for Assessing the Threshold Concentration to Enhance the Absorption of a Hydrophilic Substance. / Kimura, Yukitaka; Hosoda, Yasuo; Shima, Motohiro; Adachi, Shuji; Matsuno, Ryuichi.

In: Bioscience, Biotechnology and Biochemistry, Vol. 62, No. 3, 03.1998, p. 443-447.

Research output: Contribution to journalArticle

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