Abstract
Objective: To evaluate the association between regular physical activity and the risk of incident dementia in older Japanese adults. Methods: This was a retrospective cohort study performed in Okayama City, Japan. Overall, 51 477 older Japanese adults were followed from 2008 to 2014. A health checkup questionnaire was used to assess regular physical activity. The Dementia Scale of long-term care insurance was used as a measure of incident dementia. Cox proportional hazard models were used to calculate adjusted hazard ratios, with their 95% confidence intervals, for the incidence of dementia across the categories of physical activity. Results: During a 7-year follow-up, 13 816 subjects were considered as having incident dementia. Compared with participants who performed physical activity less than or equal to one time per week, the multivariate adjusted hazard ratio values (95% confidence intervals) for participants who performed physical activity greater than or equal to two times per week but not every day and those who performed physical activity every day were 0.79 (0.75-0.84) and 0.94 (0.89-0.98), respectively. The interaction of physical activity and sex was statistically significant (P <.01). In subgroup analysis, the multivariate-adjusted hazard ratio values (95% confidence intervals) remained low, at 0.76 (0.70-0.84) in males and 0.81 (0.76-0.87) in females who performed physical activity greater than or equal to two times per week but not every day; they were 0.82 (0.76-0.89) in males and 1.01 (0.95-1.07) in females who performed physical activity every day. Conclusions: Regular physical activity could reduce the risk of incident dementia in older Japanese adults, except females who performed physical activity every day.
| Original language | English |
|---|---|
| Journal | International Journal of Geriatric Psychiatry |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
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Keywords
- cohort study
- dementia
- elderly
- Japanese
- long-term care insurance
- physical activity
ASJC Scopus subject areas
- Geriatrics and Gerontology
- Psychiatry and Mental health
Cite this
Physical activity and incident dementia in older Japanese adults : The Okayama study. / Liu, Yangyang; Mitsuhashi, Toshiharu; Yamakawa, Michiyo; Sasai, Megumi; Tsuda, Toshihide; Doi, Hiroyuki; Hamada, Jun.
In: International Journal of Geriatric Psychiatry, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Physical activity and incident dementia in older Japanese adults
T2 - The Okayama study
AU - Liu, Yangyang
AU - Mitsuhashi, Toshiharu
AU - Yamakawa, Michiyo
AU - Sasai, Megumi
AU - Tsuda, Toshihide
AU - Doi, Hiroyuki
AU - Hamada, Jun
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Objective: To evaluate the association between regular physical activity and the risk of incident dementia in older Japanese adults. Methods: This was a retrospective cohort study performed in Okayama City, Japan. Overall, 51 477 older Japanese adults were followed from 2008 to 2014. A health checkup questionnaire was used to assess regular physical activity. The Dementia Scale of long-term care insurance was used as a measure of incident dementia. Cox proportional hazard models were used to calculate adjusted hazard ratios, with their 95% confidence intervals, for the incidence of dementia across the categories of physical activity. Results: During a 7-year follow-up, 13 816 subjects were considered as having incident dementia. Compared with participants who performed physical activity less than or equal to one time per week, the multivariate adjusted hazard ratio values (95% confidence intervals) for participants who performed physical activity greater than or equal to two times per week but not every day and those who performed physical activity every day were 0.79 (0.75-0.84) and 0.94 (0.89-0.98), respectively. The interaction of physical activity and sex was statistically significant (P <.01). In subgroup analysis, the multivariate-adjusted hazard ratio values (95% confidence intervals) remained low, at 0.76 (0.70-0.84) in males and 0.81 (0.76-0.87) in females who performed physical activity greater than or equal to two times per week but not every day; they were 0.82 (0.76-0.89) in males and 1.01 (0.95-1.07) in females who performed physical activity every day. Conclusions: Regular physical activity could reduce the risk of incident dementia in older Japanese adults, except females who performed physical activity every day.
AB - Objective: To evaluate the association between regular physical activity and the risk of incident dementia in older Japanese adults. Methods: This was a retrospective cohort study performed in Okayama City, Japan. Overall, 51 477 older Japanese adults were followed from 2008 to 2014. A health checkup questionnaire was used to assess regular physical activity. The Dementia Scale of long-term care insurance was used as a measure of incident dementia. Cox proportional hazard models were used to calculate adjusted hazard ratios, with their 95% confidence intervals, for the incidence of dementia across the categories of physical activity. Results: During a 7-year follow-up, 13 816 subjects were considered as having incident dementia. Compared with participants who performed physical activity less than or equal to one time per week, the multivariate adjusted hazard ratio values (95% confidence intervals) for participants who performed physical activity greater than or equal to two times per week but not every day and those who performed physical activity every day were 0.79 (0.75-0.84) and 0.94 (0.89-0.98), respectively. The interaction of physical activity and sex was statistically significant (P <.01). In subgroup analysis, the multivariate-adjusted hazard ratio values (95% confidence intervals) remained low, at 0.76 (0.70-0.84) in males and 0.81 (0.76-0.87) in females who performed physical activity greater than or equal to two times per week but not every day; they were 0.82 (0.76-0.89) in males and 1.01 (0.95-1.07) in females who performed physical activity every day. Conclusions: Regular physical activity could reduce the risk of incident dementia in older Japanese adults, except females who performed physical activity every day.
KW - cohort study
KW - dementia
KW - elderly
KW - Japanese
KW - long-term care insurance
KW - physical activity
UR - http://www.scopus.com/inward/record.url?scp=85065714518&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065714518&partnerID=8YFLogxK
U2 - 10.1002/gps.5135
DO - 10.1002/gps.5135
M3 - Article
JO - International Journal of Geriatric Psychiatry
JF - International Journal of Geriatric Psychiatry
SN - 0885-6230
ER -