Phylogeny of Regulatory Regions of Vertebrate Tyrosinase Genes

HIROAKI YAMAMOTO, TOSHIYUKI KUDO, NORIO MASUKO, HIROHITO MIURA, SHIGERU SATO, MIKA TANAKA, SATOSHI TANAKA, SAKAE TAKEUCHI, SHIGEKI SHIBAHARA, TAKUJI TAKEUCHI

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

Highly homologous DNA elements were found to be shared by the upstream regions of the mouse tyrosinase and tyrosinase related protein (TRP‐1) genes. Several nuclear proteins were shown to bind to both of these upstream regions. Shared homologous DNA elements were also found in the 5’ flanking sequences of Japanese quail and snapping turtle tyrosinase genes. Shared homologous nucleotide sequences were found to be scattered like an archipelago in the 5’ upstream regions of mouse and human tyrosinase genes. Comparisons between Japanese quail and snapping turtle tyrosinase genes gave similar results. On the contrary, mammalian (mouse and human) and nonmammalian (quail and snapping turtle) tyrosinase genes did not show significant homology in their 5’ upstream regions. In contrast, coding sequences in the first exons of vertebrate tyrosinase genes and their deduced amino acid sequences were found to be highly conserved except for their putative leader sequence‐coding regions.

Original languageEnglish
Pages (from-to)284-294
Number of pages11
JournalPigment Cell Research
Volume5
Issue number5
DOIs
Publication statusPublished - Nov 1992
Externally publishedYes

Keywords

  • Cloning
  • Gel retardation assay
  • Japanese quail
  • Snapping turtle
  • South‐Western blotting

ASJC Scopus subject areas

  • Agronomy and Crop Science
  • Plant Science
  • Developmental Biology
  • Clinical Biochemistry
  • Cell Biology

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