Phylogenetic relationship of Plasmodium falciparum populations in the Philippines

Moritoshi Iwagami, Toshimitsu Hatabu, Shin ichiro Kawazu, Aleyla S. Escueta, Elena A. Villacorte, Pilarita Tongol-Rivera, Shigeyuki Kano

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Malaria is one of the major infectious diseases in the Philippines. It is being targeted for control through sustained early diagnosis, treatment and mosquito control. It is in this light that understanding the genetic background of the parasite population is important not only for basic biology of the organism but also for epidemiology and control of the disease. In the present study, molecular phylogenetic relationships of the 3 Plasmodium falciparum populations in the Philippines with the other populations in the world were inferred based on polymorphisms of 9 highly polymorphic microsatellite DNA loci in the parasite genome. A total of 92 P. falciparum isolates collected from 3 provinces (Kalinga, Palawan and Davao del Morte) in the Philippines, and 8 from other populations (3 African, 2 South American, 2 Papua New Guinean, and 1 Thai) that were previously reported, were used for the analysis. The phylogenetic tree showed that the 3 Philippine populations were genetically divergent from each other as compared to the other populations. The branching pattern of the tree suggests that the 3 Philippine populations were relatively close to the Thai population, rather than the Papua New Guinean populations, indicating that the ancestor of the 3 Philippines populations were introduced from Indochina peninsula, and not from countries located south of the Philippines such as Papua New Guinea or Indonesia.

Original languageEnglish
Pages (from-to)200-204
Number of pages5
JournalThe Southeast Asian journal of tropical medicine and public health.
Volume39
Issue number2
Publication statusPublished - Mar 2008
Externally publishedYes

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Philippines
Plasmodium falciparum
Population
Parasites
Mosquito Control
Papua New Guinea
Indonesia
Microsatellite Repeats
Malaria
Communicable Diseases
Early Diagnosis
Epidemiology
Genome

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Iwagami, M., Hatabu, T., Kawazu, S. I., Escueta, A. S., Villacorte, E. A., Tongol-Rivera, P., & Kano, S. (2008). Phylogenetic relationship of Plasmodium falciparum populations in the Philippines. The Southeast Asian journal of tropical medicine and public health., 39(2), 200-204.

Phylogenetic relationship of Plasmodium falciparum populations in the Philippines. / Iwagami, Moritoshi; Hatabu, Toshimitsu; Kawazu, Shin ichiro; Escueta, Aleyla S.; Villacorte, Elena A.; Tongol-Rivera, Pilarita; Kano, Shigeyuki.

In: The Southeast Asian journal of tropical medicine and public health., Vol. 39, No. 2, 03.2008, p. 200-204.

Research output: Contribution to journalArticle

Iwagami, M, Hatabu, T, Kawazu, SI, Escueta, AS, Villacorte, EA, Tongol-Rivera, P & Kano, S 2008, 'Phylogenetic relationship of Plasmodium falciparum populations in the Philippines', The Southeast Asian journal of tropical medicine and public health., vol. 39, no. 2, pp. 200-204.
Iwagami, Moritoshi ; Hatabu, Toshimitsu ; Kawazu, Shin ichiro ; Escueta, Aleyla S. ; Villacorte, Elena A. ; Tongol-Rivera, Pilarita ; Kano, Shigeyuki. / Phylogenetic relationship of Plasmodium falciparum populations in the Philippines. In: The Southeast Asian journal of tropical medicine and public health. 2008 ; Vol. 39, No. 2. pp. 200-204.
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