Photosensitizer and anticancer drug-loaded 2D nanosheet: Preparation, stability and anticancer property

Gang Liu; Ping Zhao; Neng Liu; Fumi Yoshino; Hongmei Qin; Yajuan Zou; Shengwei Shi; Tsukuru Amano; Jose R. Aguilar Cosme; Yasunobu Nagano; Hitoshi Tamiaki; Naoki Komatsu

doi:10.1088/2053-1583/ab377b

Photosensitizer and anticancer drug-loaded 2D nanosheet: Preparation, stability and anticancer property

Gang Liu, Ping Zhao, Neng Liu, Fumi Yoshino, Hongmei Qin, Yajuan Zou, Shengwei Shi, Tsukuru Amano, Jose R. Aguilar Cosme, Yasunobu Nagano, Hitoshi Tamiaki, Naoki Komatsu

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Cancer phototherapy (PT) including photodynamic therapy (PDT) and photothermal therapy (PTT) has attracted extensive interest due to its non-invasive and region-specific nature. In order to enhance the efficacy, we have fabricated various nanocomposites consisting of a photosensitizer (chlorin e ₆ (Ce6), pheophorbide a (Pa) or bacteriopheophorbide a (bPa)) for PDT and a two-dimensional nanosheet (graphene or MoS₂) for PTT by a one-pot protocol through liquid phase exfoliation. In addition, an anticancer drug (doxorubicin (DOX) or irinotecan (Ir)) was loaded on the nanosheet in the same way for comparison. The nanocomposites demonstrated stability when dispersed in water except for MoS₂-Ir. We observed that MoS₂-Ce6 killed cancer cells over ten times more effectively than other Ce6-loaded nanocomposites.

Original language	English
Article number	045035
Journal	2D Materials
Volume	6
Issue number	4
DOIs	https://doi.org/10.1088/2053-1583/ab377b
Publication status	Published - 2019
Externally published	Yes

Keywords

2D nanosheet
anticancer drug
photodynamic therapy
photosensitizer
phototherapy
photothermal therapy

ASJC Scopus subject areas

Chemistry(all)
Materials Science(all)
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1088/2053-1583/ab377b

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title = "Photosensitizer and anticancer drug-loaded 2D nanosheet: Preparation, stability and anticancer property",

abstract = "Cancer phototherapy (PT) including photodynamic therapy (PDT) and photothermal therapy (PTT) has attracted extensive interest due to its non-invasive and region-specific nature. In order to enhance the efficacy, we have fabricated various nanocomposites consisting of a photosensitizer (chlorin e 6 (Ce6), pheophorbide a (Pa) or bacteriopheophorbide a (bPa)) for PDT and a two-dimensional nanosheet (graphene or MoS2) for PTT by a one-pot protocol through liquid phase exfoliation. In addition, an anticancer drug (doxorubicin (DOX) or irinotecan (Ir)) was loaded on the nanosheet in the same way for comparison. The nanocomposites demonstrated stability when dispersed in water except for MoS2-Ir. We observed that MoS2-Ce6 killed cancer cells over ten times more effectively than other Ce6-loaded nanocomposites.",

keywords = "2D nanosheet, anticancer drug, photodynamic therapy, photosensitizer, phototherapy, photothermal therapy",

author = "Gang Liu and Ping Zhao and Neng Liu and Fumi Yoshino and Hongmei Qin and Yajuan Zou and Shengwei Shi and Tsukuru Amano and {Aguilar Cosme}, {Jose R.} and Yasunobu Nagano and Hitoshi Tamiaki and Naoki Komatsu",

note = "Publisher Copyright: {\textcopyright} 2019 IOP Publishing Ltd.",

year = "2019",

doi = "10.1088/2053-1583/ab377b",

language = "English",

volume = "6",

journal = "2D Materials",

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TY - JOUR

T1 - Photosensitizer and anticancer drug-loaded 2D nanosheet

T2 - Preparation, stability and anticancer property

AU - Liu, Gang

AU - Zhao, Ping

AU - Liu, Neng

AU - Yoshino, Fumi

AU - Qin, Hongmei

AU - Zou, Yajuan

AU - Shi, Shengwei

AU - Amano, Tsukuru

AU - Aguilar Cosme, Jose R.

AU - Nagano, Yasunobu

AU - Tamiaki, Hitoshi

AU - Komatsu, Naoki

PY - 2019

Y1 - 2019

N2 - Cancer phototherapy (PT) including photodynamic therapy (PDT) and photothermal therapy (PTT) has attracted extensive interest due to its non-invasive and region-specific nature. In order to enhance the efficacy, we have fabricated various nanocomposites consisting of a photosensitizer (chlorin e 6 (Ce6), pheophorbide a (Pa) or bacteriopheophorbide a (bPa)) for PDT and a two-dimensional nanosheet (graphene or MoS2) for PTT by a one-pot protocol through liquid phase exfoliation. In addition, an anticancer drug (doxorubicin (DOX) or irinotecan (Ir)) was loaded on the nanosheet in the same way for comparison. The nanocomposites demonstrated stability when dispersed in water except for MoS2-Ir. We observed that MoS2-Ce6 killed cancer cells over ten times more effectively than other Ce6-loaded nanocomposites.

AB - Cancer phototherapy (PT) including photodynamic therapy (PDT) and photothermal therapy (PTT) has attracted extensive interest due to its non-invasive and region-specific nature. In order to enhance the efficacy, we have fabricated various nanocomposites consisting of a photosensitizer (chlorin e 6 (Ce6), pheophorbide a (Pa) or bacteriopheophorbide a (bPa)) for PDT and a two-dimensional nanosheet (graphene or MoS2) for PTT by a one-pot protocol through liquid phase exfoliation. In addition, an anticancer drug (doxorubicin (DOX) or irinotecan (Ir)) was loaded on the nanosheet in the same way for comparison. The nanocomposites demonstrated stability when dispersed in water except for MoS2-Ir. We observed that MoS2-Ce6 killed cancer cells over ten times more effectively than other Ce6-loaded nanocomposites.

KW - 2D nanosheet

KW - anticancer drug

KW - photodynamic therapy

KW - photosensitizer

KW - phototherapy

KW - photothermal therapy

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DO - 10.1088/2053-1583/ab377b

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SN - 2053-1583

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ER -

Photosensitizer and anticancer drug-loaded 2D nanosheet: Preparation, stability and anticancer property

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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