Photosensitizer and anticancer drug-loaded 2D nanosheet: Preparation, stability and anticancer property

Gang Liu, Ping Zhao, Neng Liu, Fumi Yoshino, Hongmei Qin, Yajuan Zou, Shengwei Shi, Tsukuru Amano, Jose R. Aguilar Cosme, Yasunobu Nagano, Hitoshi Tamiaki, Naoki Komatsu

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Cancer phototherapy (PT) including photodynamic therapy (PDT) and photothermal therapy (PTT) has attracted extensive interest due to its non-invasive and region-specific nature. In order to enhance the efficacy, we have fabricated various nanocomposites consisting of a photosensitizer (chlorin e 6 (Ce6), pheophorbide a (Pa) or bacteriopheophorbide a (bPa)) for PDT and a two-dimensional nanosheet (graphene or MoS2) for PTT by a one-pot protocol through liquid phase exfoliation. In addition, an anticancer drug (doxorubicin (DOX) or irinotecan (Ir)) was loaded on the nanosheet in the same way for comparison. The nanocomposites demonstrated stability when dispersed in water except for MoS2-Ir. We observed that MoS2-Ce6 killed cancer cells over ten times more effectively than other Ce6-loaded nanocomposites.

Original languageEnglish
Article number045035
Journal2D Materials
Volume6
Issue number4
DOIs
Publication statusPublished - 2019
Externally publishedYes

Keywords

  • 2D nanosheet
  • anticancer drug
  • photodynamic therapy
  • photosensitizer
  • phototherapy
  • photothermal therapy

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Fingerprint

Dive into the research topics of 'Photosensitizer and anticancer drug-loaded 2D nanosheet: Preparation, stability and anticancer property'. Together they form a unique fingerprint.

Cite this