Abstract
The complex formation of In3+-tetrakis(4-N-methylpyridyl)- porphine (In-TMPyP) with albumin was studied by resonance Raman spectroscopy. Albumin coordinated to In3+ through the -S- group(s). The photoreaction was investigated using the visible spectral change and In-TMPyP-thiourea complex was used as a model. It was demonstrated that the complex in a weak basic solution (pH 8.5) is excited by light and the excited complex converts oxygen to superoxide anion, which finally cleavages the porphine ring of In-TMPyP.
Original language | English |
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Pages (from-to) | 1638-1640 |
Number of pages | 3 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 50 |
Issue number | 12 |
DOIs | |
Publication status | Published - Dec 2002 |
Keywords
- Active oxygen
- Ga-
- In-
- Photo reaction
- Porphyrin
- Superoxide
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery