Photoreaction generating active oxygens of In3+-tetrakis(4- methylpyridyl)-porphine in the presence of albumins

Masaki Mifune, Hatsuki Asahara, Toyohiro Hinokiyama, Jian Liu, Hiromichi Akizawa, Akimasa Iwado, Noriko Motohashi, Yutaka Saito

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The complex formation of In3+-tetrakis(4-N-methylpyridyl)- porphine (In-TMPyP) with albumin was studied by resonance Raman spectroscopy. Albumin coordinated to In3+ through the -S- group(s). The photoreaction was investigated using the visible spectral change and In-TMPyP-thiourea complex was used as a model. It was demonstrated that the complex in a weak basic solution (pH 8.5) is excited by light and the excited complex converts oxygen to superoxide anion, which finally cleavages the porphine ring of In-TMPyP.

Original languageEnglish
Pages (from-to)1638-1640
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume50
Issue number12
DOIs
Publication statusPublished - Dec 1 2002

Keywords

  • Active oxygen
  • Ga-
  • In-
  • Photo reaction
  • Porphyrin
  • Superoxide

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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