Photoreaction generating active oxygens of In3+-tetrakis(4- methylpyridyl)-porphine in the presence of albumins

Masaki Mifune; Hatsuki Asahara; Toyohiro Hinokiyama; Jian Liu; Hiromichi Akizawa; Akimasa Iwado; Noriko Motohashi; Yutaka Saito

doi:10.1248/cpb.50.1638

Photoreaction generating active oxygens of In³⁺-tetrakis(4- methylpyridyl)-porphine in the presence of albumins

Masaki Mifune, Hatsuki Asahara, Toyohiro Hinokiyama, Jian Liu, Hiromichi Akizawa, Akimasa Iwado, Noriko Motohashi, Yutaka Saito

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The complex formation of In³⁺-tetrakis(4-N-methylpyridyl)- porphine (In-TMPyP) with albumin was studied by resonance Raman spectroscopy. Albumin coordinated to In³⁺ through the -S^- group(s). The photoreaction was investigated using the visible spectral change and In-TMPyP-thiourea complex was used as a model. It was demonstrated that the complex in a weak basic solution (pH 8.5) is excited by light and the excited complex converts oxygen to superoxide anion, which finally cleavages the porphine ring of In-TMPyP.

Original language	English
Pages (from-to)	1638-1640
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	50
Issue number	12
DOIs	https://doi.org/10.1248/cpb.50.1638
Publication status	Published - Dec 2002

Keywords

Active oxygen
Ga-
In-
Photo reaction
Porphyrin
Superoxide

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

Access to Document

10.1248/cpb.50.1638

Cite this

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title = "Photoreaction generating active oxygens of In3+-tetrakis(4- methylpyridyl)-porphine in the presence of albumins",

abstract = "The complex formation of In3+-tetrakis(4-N-methylpyridyl)- porphine (In-TMPyP) with albumin was studied by resonance Raman spectroscopy. Albumin coordinated to In3+ through the -S- group(s). The photoreaction was investigated using the visible spectral change and In-TMPyP-thiourea complex was used as a model. It was demonstrated that the complex in a weak basic solution (pH 8.5) is excited by light and the excited complex converts oxygen to superoxide anion, which finally cleavages the porphine ring of In-TMPyP.",

keywords = "Active oxygen, Ga-, In-, Photo reaction, Porphyrin, Superoxide",

author = "Masaki Mifune and Hatsuki Asahara and Toyohiro Hinokiyama and Jian Liu and Hiromichi Akizawa and Akimasa Iwado and Noriko Motohashi and Yutaka Saito",

year = "2002",

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doi = "10.1248/cpb.50.1638",

language = "English",

volume = "50",

pages = "1638--1640",

journal = "Chemical and Pharmaceutical Bulletin",

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T1 - Photoreaction generating active oxygens of In3+-tetrakis(4- methylpyridyl)-porphine in the presence of albumins

AU - Mifune, Masaki

AU - Asahara, Hatsuki

AU - Hinokiyama, Toyohiro

AU - Liu, Jian

AU - Akizawa, Hiromichi

AU - Iwado, Akimasa

AU - Motohashi, Noriko

AU - Saito, Yutaka

PY - 2002/12

Y1 - 2002/12

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AB - The complex formation of In3+-tetrakis(4-N-methylpyridyl)- porphine (In-TMPyP) with albumin was studied by resonance Raman spectroscopy. Albumin coordinated to In3+ through the -S- group(s). The photoreaction was investigated using the visible spectral change and In-TMPyP-thiourea complex was used as a model. It was demonstrated that the complex in a weak basic solution (pH 8.5) is excited by light and the excited complex converts oxygen to superoxide anion, which finally cleavages the porphine ring of In-TMPyP.

KW - Active oxygen

KW - Ga-

KW - In-

KW - Photo reaction

KW - Porphyrin

KW - Superoxide

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