Photoreaction generating active oxygens of In3+-tetrakis(4- methylpyridyl)-porphine in the presence of albumins

Masaki Mifune; Hatsuki Asahara; Toyohiro Hinokiyama; Jian Liu; Hiromichi Akizawa; Akimasa Iwado; Noriko Motohashi; Yutaka Saito

doi:10.1248/cpb.50.1638

Photoreaction generating active oxygens of In³⁺-tetrakis(4- methylpyridyl)-porphine in the presence of albumins

Masaki Mifune, Hatsuki Asahara, Toyohiro Hinokiyama, Jian Liu, Hiromichi Akizawa, Akimasa Iwado, Noriko Motohashi, Yutaka Saito

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The complex formation of In³⁺-tetrakis(4-N-methylpyridyl)- porphine (In-TMPyP) with albumin was studied by resonance Raman spectroscopy. Albumin coordinated to In³⁺ through the -S^- group(s). The photoreaction was investigated using the visible spectral change and In-TMPyP-thiourea complex was used as a model. It was demonstrated that the complex in a weak basic solution (pH 8.5) is excited by light and the excited complex converts oxygen to superoxide anion, which finally cleavages the porphine ring of In-TMPyP.

Original language	English
Pages (from-to)	1638-1640
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	50
Issue number	12
DOIs	https://doi.org/10.1248/cpb.50.1638
Publication status	Published - Dec 2002

Keywords

Active oxygen
Ga-
In-
Photo reaction
Porphyrin
Superoxide

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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Photoreaction generating active oxygens of In³⁺-tetrakis(4- methylpyridyl)-porphine in the presence of albumins. / Mifune, Masaki; Asahara, Hatsuki; Hinokiyama, Toyohiro; Liu, Jian; Akizawa, Hiromichi; Iwado, Akimasa; Motohashi, Noriko; Saito, Yutaka.

In: Chemical and Pharmaceutical Bulletin, Vol. 50, No. 12, 12.2002, p. 1638-1640.

Research output: Contribution to journal › Article › peer-review

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abstract = "The complex formation of In3+-tetrakis(4-N-methylpyridyl)- porphine (In-TMPyP) with albumin was studied by resonance Raman spectroscopy. Albumin coordinated to In3+ through the -S- group(s). The photoreaction was investigated using the visible spectral change and In-TMPyP-thiourea complex was used as a model. It was demonstrated that the complex in a weak basic solution (pH 8.5) is excited by light and the excited complex converts oxygen to superoxide anion, which finally cleavages the porphine ring of In-TMPyP.",

keywords = "Active oxygen, Ga-, In-, Photo reaction, Porphyrin, Superoxide",

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AU - Hinokiyama, Toyohiro

AU - Liu, Jian

AU - Akizawa, Hiromichi

AU - Iwado, Akimasa

AU - Motohashi, Noriko

AU - Saito, Yutaka

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