Photoinitiators enhanced 1,2-dichloropropane-induced cytotoxicity in human normal embryonic lung fibroblasts cells in vitro

Yoichi Kawasaki, Chiaki Tsuboi, Kenta Yagi, Miwa Morizane, Yasuyuki Masaoka, Satoru Esumi, Yoshihisa Kitamura, Toshiaki Sendo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Dichloromethane (DCM) and 1,2-dichloropsropane (DCP) have various uses, including being solvents for paint removers. Photoinitiators are also used in a wide range of commercial applications such as printing. These chemicals have been shown to induce cytotoxic effects. In the present study, we evaluated the combined effects of DCM or DCP from paint removers and photoinitiators used in printing on normal human embryonic lung fibroblasts with the aim of preventing occupational injuries. We showed that DCP, 2,2-dimethoxy-2-phenylacetophenone (2,2-DMPAP), 2-ethylhexyl-4-(dimethylamino) benzoate (2-EHDAB), 1-hydroxycyclohexyl phenyl ketone (1-HCHPK), and methyl 2-benzoylbenzoate (MBB) induced cytotoxicity, whereas DCM and 2-isopropylthioxanthone (2-ITX) did not. In addition, 2-methyl-4′-(methylthio)-2-morpholinopropiophenone (MTMP) caused a slight increase in cytotoxicity. The combination of DCP and the four photoinitiators (2,2-DMPAP, 2-EHDAB, MBB, and MTMP) significantly induced cytotoxicity and also led to apoptosis. In conclusion, the combination of DCP and photoinitiators may increase the risk of respiratory diseases.

Original languageEnglish
Pages (from-to)4763-4770
Number of pages8
JournalEnvironmental Science and Pollution Research
Volume22
Issue number6
DOIs
Publication statusPublished - 2015

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padimate-O
Methylene Chloride
Dichloromethane
Fibroblasts
Cytotoxicity
Printing
Paint
Cells
Lung
Occupational Injuries
Pulmonary diseases
respiratory disease
apoptosis
Cell death
ketone
Ketones
Apoptosis
propylene dichloride
In Vitro Techniques
cytotoxicity

Keywords

  • 1,2-Dichloropropane
  • Apoptosis
  • Combination effect
  • Cytotoxicity
  • Occupational injury
  • Photoinitiator

ASJC Scopus subject areas

  • Environmental Chemistry
  • Health, Toxicology and Mutagenesis
  • Pollution
  • Medicine(all)

Cite this

Photoinitiators enhanced 1,2-dichloropropane-induced cytotoxicity in human normal embryonic lung fibroblasts cells in vitro. / Kawasaki, Yoichi; Tsuboi, Chiaki; Yagi, Kenta; Morizane, Miwa; Masaoka, Yasuyuki; Esumi, Satoru; Kitamura, Yoshihisa; Sendo, Toshiaki.

In: Environmental Science and Pollution Research, Vol. 22, No. 6, 2015, p. 4763-4770.

Research output: Contribution to journalArticle

Kawasaki, Yoichi ; Tsuboi, Chiaki ; Yagi, Kenta ; Morizane, Miwa ; Masaoka, Yasuyuki ; Esumi, Satoru ; Kitamura, Yoshihisa ; Sendo, Toshiaki. / Photoinitiators enhanced 1,2-dichloropropane-induced cytotoxicity in human normal embryonic lung fibroblasts cells in vitro. In: Environmental Science and Pollution Research. 2015 ; Vol. 22, No. 6. pp. 4763-4770.
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