Photodynamic therapy with ATX-S10•Na(II) inhibits synovial sarcoma cell growth

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Photodynamic therapy (PDT) is an effective cancer treatment modality that allows selective destruction of malignant tumor cells. We asked whether PDT could inhibit in vivo and in vitro growth of synovial sarcoma cells. We analyzed PDT using ATX-S10•Na(II) and a diode laser for a synovial sarcoma cell line (SYO-1). Photodynamic therapy with ATX-S10•Na(II) showed an in vitro cytotoxic effect on the cultured SYO-1 cells. The in vitro effect of PDT depended on the treatment concentration of ATX-S10•Na(II) and the laser dose of irradiation. ATX-S10•Na(II) was detected in the tumor tissue specimens that were excised from nude mice bearing SYO-1 within 6 hours after intravenous injection, but it was eliminated from the tumor 12 hours after injection. Photodynamic therapy suppressed the tumor growth of nude mice bearing SYO-1, and high-dose irradiation induced no viable tumor cells in histologic specimens. Photodynamic therapy performed after marginal resection of the tumor of nude mice bearing SYO-1 reduced the rate of local recurrence of the tumor. Our results suggest PDT using ATX-S10•Na(II) and laser irradiation may be a potentially useful treatment for synovial sarcoma, especially to reduce the surgical margin and preserve critical anatomic structures adjacent to the tumor.

Original languageEnglish
Pages (from-to)1726-1733
Number of pages8
JournalClinical Orthopaedics and Related Research
Volume466
Issue number7
DOIs
Publication statusPublished - Jul 2008

Fingerprint

Synovial Sarcoma
Photochemotherapy
Growth
Neoplasms
Nude Mice
Lasers
ATX S10Na(II)
Semiconductor Lasers
Intravenous Injections
Therapeutics
Recurrence
Cell Line
Injections

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Photodynamic therapy with ATX-S10•Na(II) inhibits synovial sarcoma cell growth. / Takeda, Ken; Kunisada, Toshiyuki; Miyazawa, Shinichi; Nakae, Yoshinori; Ozaki, Toshihumi.

In: Clinical Orthopaedics and Related Research, Vol. 466, No. 7, 07.2008, p. 1726-1733.

Research output: Contribution to journalArticle

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