Photocytotoxicity of water-soluble fullerene derivatives

Kazuhiro Irie, Yoshimasa Nakamura, Hajime Ohigashi, Hidetoshi Tokuyama, Shigeru Yamago, Eiichi Nakamura

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

New water-soluble fullerene carboxylic acids (1 and 2) derived from C60 and C70 fullerenes, respectively, were examined for photocytotoxicity toward Raji cells (B lymphocyte). These compounds did not show any photocytotoxic effect even at 50μM, while pheophorbide a showed significant photocytotoxicity at 0.5 μM. Therefore, fullerene derivatives derived from C60 and C70 would not be practical agents for photodynamic therapy.

Original languageEnglish
Pages (from-to)1359-1361
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume60
Issue number8
Publication statusPublished - Aug 1996
Externally publishedYes

Fingerprint

fullerene
Fullerenes
Derivatives
Photodynamic therapy
Lymphocytes
Water
Photochemotherapy
Carboxylic Acids
B-Lymphocytes
water
carboxylic acids
B-lymphocytes
therapeutics
cells

Keywords

  • fullerene
  • pheophorbide a
  • photocytotoxicity
  • photodynamic
  • porphyrin
  • therapy

ASJC Scopus subject areas

  • Food Science
  • Applied Microbiology and Biotechnology
  • Chemistry (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biotechnology

Cite this

Irie, K., Nakamura, Y., Ohigashi, H., Tokuyama, H., Yamago, S., & Nakamura, E. (1996). Photocytotoxicity of water-soluble fullerene derivatives. Bioscience, Biotechnology and Biochemistry, 60(8), 1359-1361.

Photocytotoxicity of water-soluble fullerene derivatives. / Irie, Kazuhiro; Nakamura, Yoshimasa; Ohigashi, Hajime; Tokuyama, Hidetoshi; Yamago, Shigeru; Nakamura, Eiichi.

In: Bioscience, Biotechnology and Biochemistry, Vol. 60, No. 8, 08.1996, p. 1359-1361.

Research output: Contribution to journalArticle

Irie, K, Nakamura, Y, Ohigashi, H, Tokuyama, H, Yamago, S & Nakamura, E 1996, 'Photocytotoxicity of water-soluble fullerene derivatives', Bioscience, Biotechnology and Biochemistry, vol. 60, no. 8, pp. 1359-1361.
Irie K, Nakamura Y, Ohigashi H, Tokuyama H, Yamago S, Nakamura E. Photocytotoxicity of water-soluble fullerene derivatives. Bioscience, Biotechnology and Biochemistry. 1996 Aug;60(8):1359-1361.
Irie, Kazuhiro ; Nakamura, Yoshimasa ; Ohigashi, Hajime ; Tokuyama, Hidetoshi ; Yamago, Shigeru ; Nakamura, Eiichi. / Photocytotoxicity of water-soluble fullerene derivatives. In: Bioscience, Biotechnology and Biochemistry. 1996 ; Vol. 60, No. 8. pp. 1359-1361.
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