Photocytotoxicity of water-soluble fullerene derivatives

Kazuhiro Irie, Yoshimasa Nakamura, Hajime Ohigashi, Hidetoshi Tokuyama, Shigeru Yamago, Eiichi Nakamura

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66 Citations (Scopus)

Abstract

New water-soluble fullerene carboxylic acids (1 and 2) derived from C60 and C70 fullerenes, respectively, were examined for photocytotoxicity toward Raji cells (B lymphocyte). These compounds did not show any photocytotoxic effect even at 50μ m, while pheophorbide a showed significant photocytotoxicity at 0.5 μ m. Therefore, fullerene derivatives derived from C60 and C70 would not be practical agents for photodynamic therapy.

Original languageEnglish
Pages (from-to)1359-1361
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume60
Issue number8
DOIs
Publication statusPublished - Jan 1996

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Keywords

  • Fullerene
  • Pheophorbide a
  • Photocytotoxicity
  • Photodynamic therapy
  • Porphyrin

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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