Photoassisted Cross-Coupling Reaction of α-Chlorocarbonyl Compounds with Arylboronic Acids

Naoki Oku, Masahiro Murakami, Tomoya Miura

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

A Suzuki-Miyaura cross-coupling reaction of α-chloroacetates or α-chloroacetamides with arylboronic acids is made possible by visible-light irradiation. This reaction provides a useful method for the synthesis of α-arylacetates and α-arylacetamides from chlorides under mild reaction conditions. An indole-3-acetic acid derivative that is the key intermediate of the plant hormone auxin can be synthesized from 1-Boc-indole in two steps by combining an iridium-catalyzed C-H borylation and a palladium-catalyzed cross-coupling reaction.

Original languageEnglish
Pages (from-to)1616-1619
Number of pages4
JournalOrganic Letters
Volume24
Issue number8
DOIs
Publication statusPublished - Mar 4 2022

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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