Phosphorylation of Na+/Ca2+ exchanger in TAB-induced cardiac hypertrophy

Yuki Katanosaka; Bongju Kim; Shigeo Wakabayashi; Satoshi Matsuoka; Munekazu Shigekawa

doi:10.1196/annals.1387.024

Phosphorylation of Na⁺/Ca²⁺ exchanger in TAB-induced cardiac hypertrophy

Yuki Katanosaka, Bongju Kim, Shigeo Wakabayashi, Satoshi Matsuoka, Munekazu Shigekawa

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Citations (Scopus)

Abstract

Both protein kinase Cα-dependent Na⁺/Ca²⁺ exchanger1 (NCX1) phosphorylation and calcineurin activity are required for the depression of NCX activity observed in chronically phenylephrine (PE)-treated hypertrophic neonatal rat cardiomyocytes. In this study, we explored the possibility that the same changes occur in vivo hypertrophy. In the hypertrophic hearts of thoracic aortic-banded (TAB) mice, NCX1 phosphorylation increased significantly compared with control hearts. Furthermore, the TAB-induced cardiac hypertrophy was much less prominent in transgenic mice overexpressing an NCX1 mutant having defective phosphorylation sites. These data suggest that the phosphorylation status of NCX1 may play an important role in the pathogenesis of load-induced cardiac hypertrophy.

Original language	English
Title of host publication	Sodium-Calcium Exchange and the Plasma Membrane Ca2+ATPase in Ce;; Funcyion
Subtitle of host publication	Fifth International Conference
Publisher	Blackwell Publishing Inc.
Pages	373-376
Number of pages	4
ISBN (Print)	1573316490, 9781573316491
DOIs	https://doi.org/10.1196/annals.1387.024
Publication status	Published - Mar 2007

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1099
ISSN (Print)	0077-8923
ISSN (Electronic)	1749-6632

Keywords

Cardiac hypertrophy
Na/Ca exchanger
Phosphorylation
Protein kinase Cα
Thoracic aortic banding

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

Access to Document

10.1196/annals.1387.024

Cite this

Katanosaka, Y., Kim, B., Wakabayashi, S., Matsuoka, S., & Shigekawa, M. (2007). Phosphorylation of Na⁺/Ca²⁺ exchanger in TAB-induced cardiac hypertrophy. In Sodium-Calcium Exchange and the Plasma Membrane Ca2+ATPase in Ce;; Funcyion: Fifth International Conference (pp. 373-376). (Annals of the New York Academy of Sciences; Vol. 1099). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1387.024

Phosphorylation of Na⁺/Ca²⁺ exchanger in TAB-induced cardiac hypertrophy. / Katanosaka, Yuki; Kim, Bongju; Wakabayashi, Shigeo et al.

Sodium-Calcium Exchange and the Plasma Membrane Ca2+ATPase in Ce;; Funcyion: Fifth International Conference. Blackwell Publishing Inc., 2007. p. 373-376 (Annals of the New York Academy of Sciences; Vol. 1099).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Katanosaka, Y, Kim, B, Wakabayashi, S, Matsuoka, S & Shigekawa, M 2007, Phosphorylation of Na⁺/Ca²⁺ exchanger in TAB-induced cardiac hypertrophy. in Sodium-Calcium Exchange and the Plasma Membrane Ca2+ATPase in Ce;; Funcyion: Fifth International Conference. Annals of the New York Academy of Sciences, vol. 1099, Blackwell Publishing Inc., pp. 373-376. https://doi.org/10.1196/annals.1387.024

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