Phosphorylation of Na+/Ca2+ exchanger in TAB-induced cardiac hypertrophy

Yuki Katanosaka, Bongju Kim, Shigeo Wakabayashi, Satoshi Matsuoka, Munekazu Shigekawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Both protein kinase Cα-dependent Na+/Ca2+ exchanger1 (NCX1) phosphorylation and calcineurin activity are required for the depression of NCX activity observed in chronically phenylephrine (PE)-treated hypertrophic neonatal rat cardiomyocytes. In this study, we explored the possibility that the same changes occur in vivo hypertrophy. In the hypertrophic hearts of thoracic aortic-banded (TAB) mice, NCX1 phosphorylation increased significantly compared with control hearts. Furthermore, the TAB-induced cardiac hypertrophy was much less prominent in transgenic mice overexpressing an NCX1 mutant having defective phosphorylation sites. These data suggest that the phosphorylation status of NCX1 may play an important role in the pathogenesis of load-induced cardiac hypertrophy.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages373-376
Number of pages4
Volume1099
DOIs
Publication statusPublished - Mar 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1099
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Phosphorylation
Cardiomegaly
Thorax
Calcineurin
Phenylephrine
Cardiac Myocytes
Protein Kinase C
Hypertrophy
Transgenic Mice
Rats

Keywords

  • Cardiac hypertrophy
  • Na/Ca exchanger
  • Phosphorylation
  • Protein kinase Cα
  • Thoracic aortic banding

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Katanosaka, Y., Kim, B., Wakabayashi, S., Matsuoka, S., & Shigekawa, M. (2007). Phosphorylation of Na+/Ca2+ exchanger in TAB-induced cardiac hypertrophy. In Annals of the New York Academy of Sciences (Vol. 1099, pp. 373-376). (Annals of the New York Academy of Sciences; Vol. 1099). https://doi.org/10.1196/annals.1387.024

Phosphorylation of Na+/Ca2+ exchanger in TAB-induced cardiac hypertrophy. / Katanosaka, Yuki; Kim, Bongju; Wakabayashi, Shigeo; Matsuoka, Satoshi; Shigekawa, Munekazu.

Annals of the New York Academy of Sciences. Vol. 1099 2007. p. 373-376 (Annals of the New York Academy of Sciences; Vol. 1099).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Katanosaka, Y, Kim, B, Wakabayashi, S, Matsuoka, S & Shigekawa, M 2007, Phosphorylation of Na+/Ca2+ exchanger in TAB-induced cardiac hypertrophy. in Annals of the New York Academy of Sciences. vol. 1099, Annals of the New York Academy of Sciences, vol. 1099, pp. 373-376. https://doi.org/10.1196/annals.1387.024
Katanosaka Y, Kim B, Wakabayashi S, Matsuoka S, Shigekawa M. Phosphorylation of Na+/Ca2+ exchanger in TAB-induced cardiac hypertrophy. In Annals of the New York Academy of Sciences. Vol. 1099. 2007. p. 373-376. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1387.024
Katanosaka, Yuki ; Kim, Bongju ; Wakabayashi, Shigeo ; Matsuoka, Satoshi ; Shigekawa, Munekazu. / Phosphorylation of Na+/Ca2+ exchanger in TAB-induced cardiac hypertrophy. Annals of the New York Academy of Sciences. Vol. 1099 2007. pp. 373-376 (Annals of the New York Academy of Sciences).
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