Phosphorylated pullulan coating enhances titanium implant osseointegration in a pig model

Marcio Vivan Cardoso, Amol Chaudhari, Kumiko Yoshihara, Marcelo Ferraz Mesquita, Yasuhiro Yoshida, Bart Van Meerbeek, Katleen Vandamme, Joke Duyck

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: To investigate the effect of coating a titanium implant surface with a phosphorylated exopolysaccharide, pullulan, on the peri-implant bone formation and implant osseointegration. Materials and Methods: Implants were placed in the skull bone of 12 domestic pigs and healed for 1 or 3 months. Osseointegration of (un)coated implants was evaluated by quantitative histology (peri-implant bone fraction [BF] and bone-to-implant-contact [BIC]). The Wilcoxon-Mann-Whitney test with α = .05 was used to statistically compare BF and BIC of the coated and uncoated implants. Results: Significantly more BF was observed surrounding pullulan-coated implants compared with uncoated implants (P < .05) and for both healing periods (P < .05). BIC was positively affected by the exopolysaccharide coating, with significantly more BIC after the 3-month healing period compared with the uncoated implant (P < .05). Furthermore, BIC remained stable over time for the coated implants, while it significantly decreased for the uncoated ones (P < .05). Conclusion: These findings reveal the capacity of functionalizing the titanium implant surface with phosphorylated pullulan to improve the mineralization of the implant-bone interface.

Original languageEnglish
Pages (from-to)282-290
Number of pages9
JournalInternational Journal of Oral and Maxillofacial Implants
Volume32
Issue number2
DOIs
Publication statusPublished - 2017

Keywords

  • Bone
  • Organic coating
  • Osseointegration
  • Pullulan
  • Titanium implant

ASJC Scopus subject areas

  • Oral Surgery

Fingerprint Dive into the research topics of 'Phosphorylated pullulan coating enhances titanium implant osseointegration in a pig model'. Together they form a unique fingerprint.

  • Cite this

    Cardoso, M. V., Chaudhari, A., Yoshihara, K., Mesquita, M. F., Yoshida, Y., Van Meerbeek, B., Vandamme, K., & Duyck, J. (2017). Phosphorylated pullulan coating enhances titanium implant osseointegration in a pig model. International Journal of Oral and Maxillofacial Implants, 32(2), 282-290. https://doi.org/10.11607/jomi.5074