Phosphorylated pullulan bioadhesive for regeneration and reconstruction of bone and tooth

Yasuhiro Yoshida, Takumi Okihara, Mariko Nakamura, Takuya Matsumoto

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

A biodegradable material that bonds to hard tissues such as bones and teeth is urgently needed for medical and dental applications. However, such materials are not available in today's clinical practice of orthopedics and dentistry. Therefore, we synthesized biodegradable phosphorylated pullulan to develop a biomaterial that combines primary properties such as high biocompatibility, good bonding potential to hard tissue, high strength, biodegradability, and osteoconductivity. The pharmacopoeial polysaccharide pullulan was chemically functionalized with dihydrogen phosphate groups. Phosphorylated pullulan was formed network by adding calcium ion, making the composite less soluble in water. Adhesive force measurement revealed that adhesiveness of the pastes before setting can be controlled through optimization of additives. In addition, histological evaluation revealed that phosphorylated pullulan-based composite possesses high biocompatibility. These results indicate that phosphorylated pullulan can be used as a key material for regeneration and reconstruction of bone and tooth.

Original languageEnglish
Title of host publicationBioceramics 24
PublisherTrans Tech Publications Ltd
Pages516-521
Number of pages6
Edition1
ISBN (Print)9783037855171
DOIs
Publication statusPublished - 2013
Event24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012 - Fukuoka, Japan
Duration: Oct 21 2012Oct 24 2012

Publication series

NameKey Engineering Materials
Number1
Volume529-530
ISSN (Print)1013-9826
ISSN (Electronic)1662-9795

Other

Other24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012
CountryJapan
CityFukuoka
Period10/21/1210/24/12

Keywords

  • Bioadhesive
  • Bone
  • Phosphorylated pullulan
  • Reconstruction
  • Regeneration
  • Tooth

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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  • Cite this

    Yoshida, Y., Okihara, T., Nakamura, M., & Matsumoto, T. (2013). Phosphorylated pullulan bioadhesive for regeneration and reconstruction of bone and tooth. In Bioceramics 24 (1 ed., pp. 516-521). (Key Engineering Materials; Vol. 529-530, No. 1). Trans Tech Publications Ltd. https://doi.org/10.4028/www.scientific.net/KEM.529-530.516