Phosphorus Deficiency Syndrome in Two Very Low Birthweight Infants

Hirokazu Tsukahara; Tadahiko Sakaguchi; Izuru Mitsuyoshi; Hitoo Fukuhara; Shuhei Hayashi; Katsuji Nakamura

doi:10.1111/j.1442-200X.1988.tb02546.x

Phosphorus Deficiency Syndrome in Two Very Low Birthweight Infants

Hirokazu Tsukahara, Tadahiko Sakaguchi, Izuru Mitsuyoshi, Hitoo Fukuhara, Shuhei Hayashi, Katsuji Nakamura

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

Biochemical and radiographic abnormalities linked with phosphorus deficiency syndrome (PDS) developed in two very low birthweight (VLBW) infants fed exclusively with human milk. By increasing phosphorus (P) and calcium (Ca) intakes with the introduction of a specialized premature formula, osteopenia or rickets, as well as hypophosphatemia, hypo‐phosphaturia and increased serum alkaline phosphatase levels improved in both patients. We speculated that all VLBW infants who are being fed exclusively with human milk should be monitored for PDS and that if PDS develops, supplementation of human milk with both P and Ca appears to be necessary for its treatment.

Original language	English
Pages (from-to)	520-525
Number of pages	6
Journal	Pediatrics International
Volume	30
Issue number	4
DOIs	https://doi.org/10.1111/j.1442-200X.1988.tb02546.x
Publication status	Published - Aug 1988
Externally published	Yes

Keywords

Human milk
Metabolic bone disease of prematurity
Phosphorus and calcium supplementation
Phosphorus deficiency syndrome
Very low birthweight infant

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1111/j.1442-200X.1988.tb02546.x

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Tsukahara, H., Sakaguchi, T., Mitsuyoshi, I., Fukuhara, H., Hayashi, S., & Nakamura, K. (1988). Phosphorus Deficiency Syndrome in Two Very Low Birthweight Infants. Pediatrics International, 30(4), 520-525. https://doi.org/10.1111/j.1442-200X.1988.tb02546.x

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abstract = "Biochemical and radiographic abnormalities linked with phosphorus deficiency syndrome (PDS) developed in two very low birthweight (VLBW) infants fed exclusively with human milk. By increasing phosphorus (P) and calcium (Ca) intakes with the introduction of a specialized premature formula, osteopenia or rickets, as well as hypophosphatemia, hypo‐phosphaturia and increased serum alkaline phosphatase levels improved in both patients. We speculated that all VLBW infants who are being fed exclusively with human milk should be monitored for PDS and that if PDS develops, supplementation of human milk with both P and Ca appears to be necessary for its treatment.",

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AU - Sakaguchi, Tadahiko

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AU - Hayashi, Shuhei

AU - Nakamura, Katsuji

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