Phosphorus Deficiency Syndrome in Two Very Low Birthweight Infants

Hirokazu Tsukahara, Tadahiko Sakaguchi, Izuru Mitsuyoshi, Hitoo Fukuhara, Shuhei Hayashi, Katsuji Nakamura

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Biochemical and radiographic abnormalities linked with phosphorus deficiency syndrome (PDS) developed in two very low birthweight (VLBW) infants fed exclusively with human milk. By increasing phosphorus (P) and calcium (Ca) intakes with the introduction of a specialized premature formula, osteopenia or rickets, as well as hypophosphatemia, hypo‐phosphaturia and increased serum alkaline phosphatase levels improved in both patients. We speculated that all VLBW infants who are being fed exclusively with human milk should be monitored for PDS and that if PDS develops, supplementation of human milk with both P and Ca appears to be necessary for its treatment.

Original languageEnglish
Pages (from-to)520-525
Number of pages6
JournalPediatrics International
Issue number4
Publication statusPublished - Aug 1988
Externally publishedYes


  • Human milk
  • Metabolic bone disease of prematurity
  • Phosphorus and calcium supplementation
  • Phosphorus deficiency syndrome
  • Very low birthweight infant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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