“Phosphite–urea” cooperative high-turnover catalysts for the highly selective bromocyclization of homogeranylarenes

Yasuhiro Sawamura, Hidefumi Nakatsuji, Akira Sakakura, Kazuaki Ishihara

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Abstract

Nucleophilic phosphite–urea cooperative high-turnover catalysts have been designed for the highly selective bromocyclization of homogeranylarenes. The introduction of a urea moiety and bulky aryl groups in the catalyst inhibits decomposition of the catalyst and the generation of byproducts. Only 0.5 mol% of the catalyst successfully promotes the bromocyclization of 4-homogeranyltoluene to give the desired product in 96% yield.

Original languageEnglish
Pages (from-to)4181-4186
Number of pages6
JournalChemical Science
Volume4
Issue number11
DOIs
Publication statusPublished - Sep 30 2013

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ASJC Scopus subject areas

  • Chemistry(all)

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