Phenylhomophthalimide-type NOS inhibitors derived from thalidomide

Tomomi Noguchi, Hiroko Sano, Rumiko Shimazawa, Aya Tanatani, Hiroyuki Miyachi, Yuichi Hashimoto

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Thalidomide shows moderate inhibitory activity toward neuronal nitric oxide synthase (nNOS) and inducible NOS (iNOS), but not toward endothelial NOS (eNOS). Structural development studies of thalidomide yielded novel phenylhomophthalimide-type NOS inhibitors with enhanced activity and different subtype selectivity.

Original languageEnglish
Pages (from-to)4141-4145
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number16
DOIs
Publication statusPublished - Aug 16 2004

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Keywords

  • NOS inhibitors
  • Structural development
  • Thalidomide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Noguchi, T., Sano, H., Shimazawa, R., Tanatani, A., Miyachi, H., & Hashimoto, Y. (2004). Phenylhomophthalimide-type NOS inhibitors derived from thalidomide. Bioorganic and Medicinal Chemistry Letters, 14(16), 4141-4145. https://doi.org/10.1016/j.bmcl.2004.06.026