Abstract
The World Health Organization (WHO) classification of malignant lymphoma presented a list of disease entities well defined by clinical, immunological and genetic features. Therefore, the current diagnosis of peripheral T/NK-cell lymphomas (PTNKLs) essentially requires the inclusion of anatomical sites of disease and phenotypical features. We analyzed 408 Japanese cases of PTNKLs in order to clarify the relationship between anatomical sites of disease and phenotypical features and to translate the functional subsets of T and NK cells into their diagnoses for further understanding lymphomatic biology. The T/NK-cell lymphoma entities were allocated into three categories: (i) cytotoxic memory T-cell and/or NK-cell lymphoma (n = 151) consisting of extranodal NK/T-cell tumors other than mycosis fungoides (MF); (ii) non-cytotoxic memory T-cell lymphoma (n = 142) consisting of nodal and cutaneous tumors such as angioimmunoblastic T-cell lymphoma, adult T-cell lymphoma/leukemia and MF; and (iii) anaplastic lymphoma kinase positive anaplastic large cell lymphoma (n = 110) that has unique features and might be regarded as cytotoxic 'naive' T-cell lymphoma. Overall, these three categories were significantly correlated with age of onset, anatomical sites, the level of expression of cytotoxic molecules and CD45RO, and association with Epstein-Barr virus. This concept might provide a new insight enabling further understanding of the interrelationships among WHO T/NK-cell disease entities.
| Original language | English |
|---|---|
| Pages (from-to) | 333-344 |
| Number of pages | 12 |
| Journal | Pathology International |
| Volume | 53 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 1 2003 |
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Keywords
- Cytotoxic molecules
- Peripheral T/NK-cell lymphoma
- World Health Organization classification
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Phenotypic analysis of peripheral T/NK cell lymphoma : Study of 408 Japanese cases with special reference to their anatomical sites. / Ichimura, Koichi; Kagami, Yoshitoyo; Suzuki, Ritsuro; Kojima, Masaru; Yoshino, Tadashi; Ohshima, Koichi; Koike, Koichi; Kondo, Eisei; Taji, Hirofumi; Ogura, Michinori; Morishima, Yasuo; Akagi, Tadaatsu; Takahashi, Toshitada; Nakamura, Shigeo.
In: Pathology International, Vol. 53, No. 6, 01.06.2003, p. 333-344.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Phenotypic analysis of peripheral T/NK cell lymphoma
T2 - Study of 408 Japanese cases with special reference to their anatomical sites
AU - Ichimura, Koichi
AU - Kagami, Yoshitoyo
AU - Suzuki, Ritsuro
AU - Kojima, Masaru
AU - Yoshino, Tadashi
AU - Ohshima, Koichi
AU - Koike, Koichi
AU - Kondo, Eisei
AU - Taji, Hirofumi
AU - Ogura, Michinori
AU - Morishima, Yasuo
AU - Akagi, Tadaatsu
AU - Takahashi, Toshitada
AU - Nakamura, Shigeo
PY - 2003/6/1
Y1 - 2003/6/1
N2 - The World Health Organization (WHO) classification of malignant lymphoma presented a list of disease entities well defined by clinical, immunological and genetic features. Therefore, the current diagnosis of peripheral T/NK-cell lymphomas (PTNKLs) essentially requires the inclusion of anatomical sites of disease and phenotypical features. We analyzed 408 Japanese cases of PTNKLs in order to clarify the relationship between anatomical sites of disease and phenotypical features and to translate the functional subsets of T and NK cells into their diagnoses for further understanding lymphomatic biology. The T/NK-cell lymphoma entities were allocated into three categories: (i) cytotoxic memory T-cell and/or NK-cell lymphoma (n = 151) consisting of extranodal NK/T-cell tumors other than mycosis fungoides (MF); (ii) non-cytotoxic memory T-cell lymphoma (n = 142) consisting of nodal and cutaneous tumors such as angioimmunoblastic T-cell lymphoma, adult T-cell lymphoma/leukemia and MF; and (iii) anaplastic lymphoma kinase positive anaplastic large cell lymphoma (n = 110) that has unique features and might be regarded as cytotoxic 'naive' T-cell lymphoma. Overall, these three categories were significantly correlated with age of onset, anatomical sites, the level of expression of cytotoxic molecules and CD45RO, and association with Epstein-Barr virus. This concept might provide a new insight enabling further understanding of the interrelationships among WHO T/NK-cell disease entities.
AB - The World Health Organization (WHO) classification of malignant lymphoma presented a list of disease entities well defined by clinical, immunological and genetic features. Therefore, the current diagnosis of peripheral T/NK-cell lymphomas (PTNKLs) essentially requires the inclusion of anatomical sites of disease and phenotypical features. We analyzed 408 Japanese cases of PTNKLs in order to clarify the relationship between anatomical sites of disease and phenotypical features and to translate the functional subsets of T and NK cells into their diagnoses for further understanding lymphomatic biology. The T/NK-cell lymphoma entities were allocated into three categories: (i) cytotoxic memory T-cell and/or NK-cell lymphoma (n = 151) consisting of extranodal NK/T-cell tumors other than mycosis fungoides (MF); (ii) non-cytotoxic memory T-cell lymphoma (n = 142) consisting of nodal and cutaneous tumors such as angioimmunoblastic T-cell lymphoma, adult T-cell lymphoma/leukemia and MF; and (iii) anaplastic lymphoma kinase positive anaplastic large cell lymphoma (n = 110) that has unique features and might be regarded as cytotoxic 'naive' T-cell lymphoma. Overall, these three categories were significantly correlated with age of onset, anatomical sites, the level of expression of cytotoxic molecules and CD45RO, and association with Epstein-Barr virus. This concept might provide a new insight enabling further understanding of the interrelationships among WHO T/NK-cell disease entities.
KW - Cytotoxic molecules
KW - Peripheral T/NK-cell lymphoma
KW - World Health Organization classification
UR - http://www.scopus.com/inward/record.url?scp=10744223976&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=10744223976&partnerID=8YFLogxK
U2 - 10.1046/j.1440-1827.2003.01479.x
DO - 10.1046/j.1440-1827.2003.01479.x
M3 - Article
C2 - 12787307
AN - SCOPUS:10744223976
VL - 53
SP - 333
EP - 344
JO - Pathology International
JF - Pathology International
SN - 1320-5463
IS - 6
ER -