Phenotypic analysis of peripheral T/NK cell lymphoma: Study of 408 Japanese cases with special reference to their anatomical sites

Koichi Ichimura, Yoshitoyo Kagami, Ritsuro Suzuki, Masaru Kojima, Tadashi Yoshino, Koichi Ohshima, Koichi Koike, Eisei Kondo, Hirofumi Taji, Michinori Ogura, Yasuo Morishima, Tadaatsu Akagi, Toshitada Takahashi, Shigeo Nakamura

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The World Health Organization (WHO) classification of malignant lymphoma presented a list of disease entities well defined by clinical, immunological and genetic features. Therefore, the current diagnosis of peripheral T/NK-cell lymphomas (PTNKLs) essentially requires the inclusion of anatomical sites of disease and phenotypical features. We analyzed 408 Japanese cases of PTNKLs in order to clarify the relationship between anatomical sites of disease and phenotypical features and to translate the functional subsets of T and NK cells into their diagnoses for further understanding lymphomatic biology. The T/NK-cell lymphoma entities were allocated into three categories: (i) cytotoxic memory T-cell and/or NK-cell lymphoma (n = 151) consisting of extranodal NK/T-cell tumors other than mycosis fungoides (MF); (ii) non-cytotoxic memory T-cell lymphoma (n = 142) consisting of nodal and cutaneous tumors such as angioimmunoblastic T-cell lymphoma, adult T-cell lymphoma/leukemia and MF; and (iii) anaplastic lymphoma kinase positive anaplastic large cell lymphoma (n = 110) that has unique features and might be regarded as cytotoxic 'naive' T-cell lymphoma. Overall, these three categories were significantly correlated with age of onset, anatomical sites, the level of expression of cytotoxic molecules and CD45RO, and association with Epstein-Barr virus. This concept might provide a new insight enabling further understanding of the interrelationships among WHO T/NK-cell disease entities.

Original languageEnglish
Pages (from-to)333-344
Number of pages12
JournalPathology International
Volume53
Issue number6
DOIs
Publication statusPublished - Jun 1 2003

Fingerprint

Peripheral T-Cell Lymphoma
Natural Killer Cells
T-Cell Lymphoma
Mycosis Fungoides
T-Lymphocytes
Lymphoma
Anaplastic Large-Cell Lymphoma
Adult T Cell Leukemia Lymphoma
Human Herpesvirus 4
Age of Onset
Neoplasms
Skin

Keywords

  • Cytotoxic molecules
  • Peripheral T/NK-cell lymphoma
  • World Health Organization classification

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Phenotypic analysis of peripheral T/NK cell lymphoma : Study of 408 Japanese cases with special reference to their anatomical sites. / Ichimura, Koichi; Kagami, Yoshitoyo; Suzuki, Ritsuro; Kojima, Masaru; Yoshino, Tadashi; Ohshima, Koichi; Koike, Koichi; Kondo, Eisei; Taji, Hirofumi; Ogura, Michinori; Morishima, Yasuo; Akagi, Tadaatsu; Takahashi, Toshitada; Nakamura, Shigeo.

In: Pathology International, Vol. 53, No. 6, 01.06.2003, p. 333-344.

Research output: Contribution to journalArticle

Ichimura, K, Kagami, Y, Suzuki, R, Kojima, M, Yoshino, T, Ohshima, K, Koike, K, Kondo, E, Taji, H, Ogura, M, Morishima, Y, Akagi, T, Takahashi, T & Nakamura, S 2003, 'Phenotypic analysis of peripheral T/NK cell lymphoma: Study of 408 Japanese cases with special reference to their anatomical sites', Pathology International, vol. 53, no. 6, pp. 333-344. https://doi.org/10.1046/j.1440-1827.2003.01479.x
Ichimura, Koichi ; Kagami, Yoshitoyo ; Suzuki, Ritsuro ; Kojima, Masaru ; Yoshino, Tadashi ; Ohshima, Koichi ; Koike, Koichi ; Kondo, Eisei ; Taji, Hirofumi ; Ogura, Michinori ; Morishima, Yasuo ; Akagi, Tadaatsu ; Takahashi, Toshitada ; Nakamura, Shigeo. / Phenotypic analysis of peripheral T/NK cell lymphoma : Study of 408 Japanese cases with special reference to their anatomical sites. In: Pathology International. 2003 ; Vol. 53, No. 6. pp. 333-344.
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