Phenolic constituents of liquorice. VII. A new chalcone with a potent radical scavenging activity and accompanying phenolics from liquorice

Tsutomu Hatano, Miyuki Takagi, Hideyuki Ito, Takashi Yoshida

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Twenty-three phenolics including six new compounds were isolated from a commercial liquorice from North-eastern China. Structures 2-7 were assigned for the new compounds, designated as tetrahydroxy-methoxychalcone, isolicopyranocoumarin, glycyrrhiza-flavonol A, and glycyrrhiza-isoflavones A, B and C, respectively. Compound 2 showed the most potent scavenging effect on 1,1-diphenyl-2-picrylhydrazyl radical among the tested polyphenols isolated from liquorice. Air-oxidation of 2 in alkaline dimethylsulfoxide solution gave strong ESR signals, indicating the stability of the radical species formed from 2.

Original languageEnglish
Pages (from-to)1485-1492
Number of pages8
JournalChemical and Pharmaceutical Bulletin
Volume45
Issue number9
Publication statusPublished - Sep 1997

Fingerprint

Glycyrrhiza
Chalcone
Isoflavones
Scavenging
Polyphenols
Dimethyl Sulfoxide
Paramagnetic resonance
Oxidation
Air
China
3-hydroxyflavone
2,2-diphenyl-1-picrylhydrazyl

Keywords

  • Flavonoid
  • Glycyrrhiza
  • Leguminosae
  • Liquorice
  • Phenolic
  • Radical scavenge

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Phenolic constituents of liquorice. VII. A new chalcone with a potent radical scavenging activity and accompanying phenolics from liquorice. / Hatano, Tsutomu; Takagi, Miyuki; Ito, Hideyuki; Yoshida, Takashi.

In: Chemical and Pharmaceutical Bulletin, Vol. 45, No. 9, 09.1997, p. 1485-1492.

Research output: Contribution to journalArticle

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