Phenolic constituents of liquorice. VII. A new chalcone with a potent radical scavenging activity and accompanying phenolics from liquorice

Tsutomu Hatano, Miyuki Takagi, Hideyuki Ito, Takashi Yoshida

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59 Citations (Scopus)


Twenty-three phenolics including six new compounds were isolated from a commercial liquorice from North-eastern China. Structures 2-7 were assigned for the new compounds, designated as tetrahydroxy-methoxychalcone, isolicopyranocoumarin, glycyrrhiza-flavonol A, and glycyrrhiza-isoflavones A, B and C, respectively. Compound 2 showed the most potent scavenging effect on 1,1-diphenyl-2-picrylhydrazyl radical among the tested polyphenols isolated from liquorice. Air-oxidation of 2 in alkaline dimethylsulfoxide solution gave strong ESR signals, indicating the stability of the radical species formed from 2.

Original languageEnglish
Pages (from-to)1485-1492
Number of pages8
JournalChemical and Pharmaceutical Bulletin
Issue number9
Publication statusPublished - Sep 1997



  • Flavonoid
  • Glycyrrhiza
  • Leguminosae
  • Liquorice
  • Phenolic
  • Radical scavenge

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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