Abstract
Two new phenolic compounds, glicoricone (3) and licofuranone (4), were isolated from a species of licorice brought from the northwestern region of China, and their structures were assigned. Among the twelve licorice constituents examined for the inhibition of monoamine oxidase (MAO), six compounds, 3, 4, genistein (6), licopyranocoumarin (7), licocoumarone (14) and glycyrrhisoflavone (15), inhibited the enzyme with the IC50 (concentration required for 50% inhibition of the enzyme activity) values of 6.0x10“5—1.4x10“4m. Glycyrrhizin (1) also inhibited MAO with the IC50 value of 1.6 x 10“4m.
Original language | English |
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Pages (from-to) | 1238-1243 |
Number of pages | 6 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 39 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1991 |
Keywords
- Glycyrrhiza
- enzyme inhibitor
- genistein
- glicoricone
- glycyrrhizin
- licocoumarone
- licofuranone
- licopyranocoumarin
- licorice
- monoamine oxidase
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery