Phenolic Constituents of Licorice: III: Structures of Glicoricone and Licofuranone, and Inhibitory Effects of Licorice Constituents on Monoamine Oxidase

Tsutomu Hatano; Toshiyuki Fukuda; Takuo Okuda; Toshio Miyase; Tadataka Noro

doi:10.1248/cpb.39.1238

Phenolic Constituents of Licorice: III: Structures of Glicoricone and Licofuranone, and Inhibitory Effects of Licorice Constituents on Monoamine Oxidase

Tsutomu Hatano, Toshiyuki Fukuda, Takuo Okuda, Toshio Miyase, Tadataka Noro

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

Two new phenolic compounds, glicoricone (3) and licofuranone (4), were isolated from a species of licorice brought from the northwestern region of China, and their structures were assigned. Among the twelve licorice constituents examined for the inhibition of monoamine oxidase (MAO), six compounds, 3, 4, genistein (6), licopyranocoumarin (7), licocoumarone (14) and glycyrrhisoflavone (15), inhibited the enzyme with the IC₅₀ (concentration required for 50% inhibition of the enzyme activity) values of 6.0x10“⁵—1.4x10“4m. Glycyrrhizin (1) also inhibited MAO with the IC₅₀ value of 1.6 x 10“4m.

Original language	English
Pages (from-to)	1238-1243
Number of pages	6
Journal	Chemical and Pharmaceutical Bulletin
Volume	39
Issue number	5
DOIs	https://doi.org/10.1248/cpb.39.1238
Publication status	Published - 1991

Keywords

Glycyrrhiza
enzyme inhibitor
genistein
glicoricone
glycyrrhizin
licocoumarone
licofuranone
licopyranocoumarin
licorice
monoamine oxidase

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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Phenolic Constituents of Licorice : III: Structures of Glicoricone and Licofuranone, and Inhibitory Effects of Licorice Constituents on Monoamine Oxidase. / Hatano, Tsutomu; Fukuda, Toshiyuki; Okuda, Takuo; Miyase, Toshio; Noro, Tadataka.

In: Chemical and Pharmaceutical Bulletin, Vol. 39, No. 5, 1991, p. 1238-1243.

Research output: Contribution to journal › Article › peer-review

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abstract = "Two new phenolic compounds, glicoricone (3) and licofuranone (4), were isolated from a species of licorice brought from the northwestern region of China, and their structures were assigned. Among the twelve licorice constituents examined for the inhibition of monoamine oxidase (MAO), six compounds, 3, 4, genistein (6), licopyranocoumarin (7), licocoumarone (14) and glycyrrhisoflavone (15), inhibited the enzyme with the IC50 (concentration required for 50% inhibition of the enzyme activity) values of 6.0x10“5—1.4x10“4m. Glycyrrhizin (1) also inhibited MAO with the IC50 value of 1.6 x 10“4m.",

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