Phenolic Constituents of Licorice. II. Structures of Licopyranocoumarin, Licoarylcoumarin and Glisoflavone, and Inhibitory Effects of Licorice Phenolics on Xanthine Oxidase

Tsutomu Hatano, Taeko Yasuhara, Toshiyuki Fukuda, Tadataka Noro, Takuo Okuda

Research output: Contribution to journalArticlepeer-review

88 Citations (Scopus)

Abstract

An anti-HIV (human immunodeficiency virus) phenolic constituent, licopyranocoumarin (4), and two other new phenolics named licoarylcoumarin (5) and glisoflavone (6) were isolated from Si-pei licorice (a commercial licorice; root and stolon of Glycyrrhiza sp. from the north-western region of China) using droplet countercurrent chromatography and centrifugal partition chromatography, and their structures were assigned based on chemical and spectroscopic data, Kaempferol 3-O-methyl ether (7) and licocoumarone (8) were also isolated from the licorice. The inhibitory effects of ten licorice phenolics on xanthine oxidase were examined. Licochalcone B (1), glycyrrhisoflavone (2), 8 and licochalcone A (19) showed 50% inhibition at the concentration of 1.3—5.6 x 105M.

Original languageEnglish
Pages (from-to)3005-3009
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume37
Issue number11
DOIs
Publication statusPublished - 1989

Keywords

  • Glycyrrhiza
  • centrifugal partition chromatography
  • droplet countercurrent chromatography
  • glisoflavone
  • kaempferol 3-O-methyl ether
  • licoarylcoumarin
  • licocoumarone
  • licopyranocoumarin
  • licorice
  • xanthine oxidase

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

Fingerprint Dive into the research topics of 'Phenolic Constituents of Licorice. II. Structures of Licopyranocoumarin, Licoarylcoumarin and Glisoflavone, and Inhibitory Effects of Licorice Phenolics on Xanthine Oxidase'. Together they form a unique fingerprint.

Cite this